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1. One of two or more contributing factors.
2. A substance, such as a metallic ion or coenzyme, that must be associated with an enzyme for the enzyme to function.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


1. (Mathematics) maths a number associated with an element in a square matrix, equal to the determinant of the matrix formed by removing the row and column in which the element appears from the given determinant. See minor
2. (Biochemistry) biochem a nonprotein substance that forms a complex with certain enzymes and is essential for their activity. It may be a metal ion or a coenzyme
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈkoʊˌfæk tər)

1. a contributing factor.
2. any of various organic or inorganic substances necessary to the function of an enzyme.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cofactor - a substance (as a coenzyme) that must join with another to produce a given result
chemical compound, compound - (chemistry) a substance formed by chemical union of two or more elements or ingredients in definite proportion by weight
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
At present, it is unclear which other lipid-related cofactors might play a role in apo E 2/2-related hyperlipidemia.
To control part of the genetic background by reducing the segregation variance generated by linked and unlinked QTLs, when the analysis is performed for a given position in the linkage map, appropriate markers outside of the interval analyzed can be fitted as cofactors in models [3] and [5].
Russell and Martin offer yet another piece of circumstantial evidence that life may have emerged from iron sulfide-catalyzed chemistry: Many of the large proteins that drive basic biochemical reactions today--such as ferredoxin, a protein that mediates metabolic reactions--rely on smaller iron sulfur cofactors. "It's a little bit of rock [in cells] that reminds us where we came from," Russell says.
Cofactors for human immunodeficiency virus entry, into primary macrophages.
Confirmation of these results, the author argues, will bring about "wider acceptance that high parity and long-term use of oral contraceptives can act as cofactors in the genesis of cervical cancer." (3)
When you eat a serving (or two) of soy in a day, you get a little of them along with their cofactors. For instance, one protein powder I used each day has 27.6 mg of genistein and 16.1 mg of daidzein.
Despite its universal importance in DNA synthesis, different organisms have evolved diverse enzymatic cofactors to catalyze this reaction.
Today, AIDS researchers work across a multifaceted terrain of complex cofactors to fight HIV.
Even so, although a matrix may not be a QI matrix, many of the arrays corresponding to its cofactors can be.
vitamins, minerals, cofactors, etc.) and monitor drug and additive compatibility, working with a homecare program to provide the solutions, supplies and equipment.
Deficiencies in nutrient cofactors will also expose functional weakness of those enzymes predisposed to dysfunction due to genetic defects.