The first one includes so-called collagenases
, such as MMP-1 (interstitial, fibroblast collagenase
1), MMP-8 (neutrophil collagenase
2), MMP-13 (collagenase
3) and MMP-18 (collagenase
Xiapex is a combination of two purified clostridial collagenases
for injection that enzymatically disrupts the contracting cord and collagen plaque and reduces the contraction.
Because most types of pharmacological agents implicated in gingival overgrowth have negative effects on calcium ion influx across cell membranes, it was postulated that such agents may interfere with the synthesis and function of collagenases
According to the company, Xiapex (collagenase
clostridium histolyticum) is a combination of two purified clostridial collagenases
for injection that enzymatically disrupts the contracting cord and reduces the contraction.
Selective inhibition of SalA on gelatinases than collagenases
In vitro sensitivity of the three mammalian collagenases
to tetracycline inhibition: relationship to bone and cartilage degradation.
Lastly, this ingredient improves skin firmness by increasing collagen levels in skin and by inhibiting the production of two collagenases
, MMP-1 and MMP-9, both of which are known to break down skin collagen.
Regulated Expression of Collagenases
MMP-1,-8, and-13 aStromelysins MMP-3,-10, and -11 by Human Corneal Epithelial Cells.
In situations in which there is active infection or significant contamination, biologic grafts may not be appropriate as they deteriorate as a result of the bacterial collagenases
1 Plasmin, in turn, mediates the pericellular proteolysis of extracellular matrix components and activates other proteases such as matrix metalloproteinases and collagenases
that lead to the further degradation and remodeling of the extracellular matrix.
3), (4), (7), (9), (19), (20) MMP-13, sometimes referred to as collagenase
-3, exhibits the broadest specificity of the collagenases
, with the highest activity against type II collagen, the primary collagen found in cartilage, and has been expressed in pathologies associated with excessive ECM degradation.
break down the native collagen that holds animal tissues together, are made by a variety of microorganisms and by many different animal cells.