collagenase

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Related to Collagenases: Interstitial collagenase

col·lag·e·nase

 (kə-lăj′ə-nās′, -nāz′, kŏl′ə-jə-)
n.
Any of various enzymes that catalyze the hydrolysis of collagen and gelatin.

collagenase

(ˈkɒlədʒəˌneɪz)
n
(Biochemistry) an enzyme that decomposes collagen
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.collagenase - any enzyme that catalyzes the hydrolysis of collagen and gelatin
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
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References in periodicals archive ?
The first one includes so-called collagenases, such as MMP-1 (interstitial, fibroblast collagenase 1), MMP-8 (neutrophil collagenase 2), MMP-13 (collagenase 3) and MMP-18 (collagenase 4).
Xiapex is a combination of two purified clostridial collagenases for injection that enzymatically disrupts the contracting cord and collagen plaque and reduces the contraction.
Because most types of pharmacological agents implicated in gingival overgrowth have negative effects on calcium ion influx across cell membranes, it was postulated that such agents may interfere with the synthesis and function of collagenases.
According to the company, Xiapex (collagenase clostridium histolyticum) is a combination of two purified clostridial collagenases for injection that enzymatically disrupts the contracting cord and reduces the contraction.
In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation.
Lastly, this ingredient improves skin firmness by increasing collagen levels in skin and by inhibiting the production of two collagenases, MMP-1 and MMP-9, both of which are known to break down skin collagen.
Regulated Expression of Collagenases MMP-1,-8, and-13 aStromelysins MMP-3,-10, and -11 by Human Corneal Epithelial Cells.
In situations in which there is active infection or significant contamination, biologic grafts may not be appropriate as they deteriorate as a result of the bacterial collagenases.
1 Plasmin, in turn, mediates the pericellular proteolysis of extracellular matrix components and activates other proteases such as matrix metalloproteinases and collagenases that lead to the further degradation and remodeling of the extracellular matrix.
3), (4), (7), (9), (19), (20) MMP-13, sometimes referred to as collagenase-3, exhibits the broadest specificity of the collagenases, with the highest activity against type II collagen, the primary collagen found in cartilage, and has been expressed in pathologies associated with excessive ECM degradation.
Collagenases break down the native collagen that holds animal tissues together, are made by a variety of microorganisms and by many different animal cells.