So-called intramolar choriocarcinoma may be encountered in a curettage specimen, (17) where villi of complete mole
are surrounded by markedly atypical trophoblastic cells with focal biphasic to triphasic growth patterns, simulating choriocarcinoma.
Detection rates are, however, higher for complete compared to partial moles and improve even further after the 14th week of gestation. The diagnosis of the complete mole
was obvious in this case as shown in [Figure 2].
The prevalence of hydatidiform mole was 6.1% (11/181), and all patients had complete mole
confirmed by immunohistochemistry for p57 (Figure 3).
There are two distinct entities of molar pregnancy: partial and complete mole
. Partial moles are characterized by the presence of fetal or embryonic tissues, chorionic villi of different sizes featured by their focal trophoblastic hyperplasia and focal swelling, and marked villous scalloping .
This age group also accounted for 12 cases of complete mole
. Only one complete mole
was seen in the age range of 41-50 years.
As p57 will be positive in normal placenta and partial mole and absent in complete mole
, p57 was done and found to be negative (Fig.
Key words: Complete mole
, Gestational trophoblastic neoplasia, Haemoperitoneum, Invasive mole, Trophoblast.
In complete mole
, all or most of the chorionic villi are edematous.
Patients with GTD were further subdivided into two groups composed of 20 partial mole (PM) and 17 complete mole
The mean age of patients with complete mole
was 26.4 years (range, 15-41 years) and in patients with partial mole, it was 30 years (range, 24-37 years).
This leads to a genetically diploid pattern (more commonly 46XX) in a complete mole
. Similar fertilization and duplication with a 23Y sperm do not produce a viable (46YY) zygote.
However, patients who presented with a complete mole
were at risk of a subsequent complete mole
, partial mole, or choriocarcinoma.9