Conn's syndrome


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Noun1.Conn's syndrome - disturbances in saltwater balance and symptoms of weakness and muscular cramps and twitching and convulsions and sometimes paralysis; usually caused by a benign tumor of the cortex of the adrenal gland that leads to excess secretion of aldosterone
syndrome - a pattern of symptoms indicative of some disease
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Although they are generally unilateral in presentation and hormonally inactive, about 10% may be associated with endocrine diseases including Cushing's syndrome, congenital adrenal hyperplasia, Conn's syndrome, pheochromocytoma, and hyperthyroidism (4).
While initially the medical team felt that Conn's syndrome was a likely cause of the abnormalities, this was reconsidered on a ward round where, following research on the internet into her abnormalities, patient X brought it to the attention of the team that she had been consuming between six and eight liquorice tea infusions per day for the past two months and had been consuming around three a day for a significant period time prior to this (roughly 18 months).
Surgical treatment of primary aldosteronism is the definitive therapy of HP induced by Conn's syndrome; therefore, the serious events that hypertension and paralysis trigger will be prevented (7).
Hormonal function tests for Cushing's syndrome, pheochromocytoma, and Conn's syndrome were negative.
We report a case of PA due to adrenocortical adenoma (Conn's syndrome) coexisting with Graves' disease in the same patient and review the available literature in view of identifying possible associations.
The metabolic work-up was negative for pheochromocytoma, Cushing syndrome and Conn's syndrome.
Even though myelolipomas are hormonally inactive, but about 10% cases are associated with endocrinopathies, such as Cushing's syndrome, congenital adrenal hyperplasia, Conn's syndrome, pheochromocytoma, hyperparathyroidism or adrenogenital syndromes.7
In humans, a similar condition known as Conn's syndrome is a potential cause of hypertension.