When the patients were able to eat food, 200 mg of cordarone
(approval number: H19993254; Hangzhou Sanofi Pharmaceutical Co., Ltd., China) was orally administrated, once each day, and 2.5 mg of warfarin (approval number: H31022123; Shanghai Sine Pharmaceutical Laboratories Co., Ltd., China); the dose could be adjusted according to PT and International Normalized Ratio (INR).
Exclusion criteria was patients taking medicines such as Lithium and Cordarone
. Sample size was 55 selected using consecutive sampling technique.
> Rhythm control medications, including flecainide (Tambocor), propafenone (Rythmol), Sotalol (Betapace), amiodarone (Cordarone
, Pacerone), and dronedarone (Multaq)
Slow intravenous bolus of 150 mg amiodarone (cordarone
; Wyeth Pharmaceuticals Inc.) was given followed by infusion of a further 300 mg over 8 h.
(Amiodarone) has also been associated with nightmares and insomnia.
Other causes of decreased thyroid function is viral infection and intake of multiple medications, particularly amiodarone (cordarone
) which is used to treat heart disease, in addition to contrast material which is given during radiological investigation (such as CT scan).
As of late October 2015, 90% of crucial medicines for heart, blood pressure and diabetes were suddenly scarce on the pharmaceutical market; among them Cordarone
, which is used to treat abnormal heart rhythm disorder and prevents a number of serious cardiac complications, such as a cerebral stroke that could lead to death.
Cholesterol (Zocor, Lipitor, Pravachol) and blood pressure lowering medicines (Nifediac, Afeditab), anti-anxiety (BuSpar) and arrhythmia drugs (Cordarone
and Nexterone), organ transplant rejection drugs (Sandimmune and Neoral) and antihistamines (Allegra) were some of the drugs affected by consumption of grapefruit.
Reda, "Determination of iodine urinary excretion in cordarone
induced hyperthyroidism," Clinica Terapeutica, vol.
Patients with A-fib are also often prescribed drugs, like amiodarone hydrochloride (Cordarone
) and verapamil (Calan and other brand names), to normalize the rate and rhythm of the heart's contractions.
CARDIOVASCULAR DRUGS THAT MAY REACT WITH GRAPEFRUIT RISK DRUG POTENTIAL COMPLICATION VERY HIGH dronedarone (Multaq) torsades de pointes lovastatin (Mevacor) rhabdomyolysis simvastatin (Zocor) rhabdomyolysis HIGH amiodarone torsades de pointes (Cordarone
) atorvastatin rhabdomyolysis (Lipitor) clopidogrel (Plavix) loss of efficacy * eplerenone (Inspra) high blood calcium levels, serious arrhythmias ticagrelor gastrointestinal or (Brilinta) kidney bleeding INTERMEDIATE felodipine (Plendil) low blood pressure, peripheral edema nifedipine low blood pressure, (Procardia) peripheral edema quinidine torsades de pointes (Quinidine) rivaroxaban gastrointestinal (Xarelto) bleeding * In 2010, it was reported that grapefruit renders certain drugs less effective or ineffective.