Also found in: Thesaurus, Medical, Wikipedia.
Related to Cox-1: Cox-2


One of two isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins. It is present in cells throughout the body and is inhibited by NSAIDs.

ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Cox-1 - an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys; "an unfortunate side effect of NSAIDs is that they block Cox-1"
Cox, cyclooxygenase - either of two related enzymes that control the production of prostaglandins and are blocked by aspirin
References in periodicals archive ?
Acetaminophen's over-the-counter competitors--aspirin and ibuprofen--stop inflammation by binding to COX-1 and COX-2 and short-circuiting the prostaglandin-making pathway.
The rationale of this combination," explained Dr Gerard Soula, Flamel's Founder, Chairman, and Chief Executive Officer, "is that COX-1 provides for the formation of thromboxane, which is the cause of thrombosis.
Aspirin, in contrast, reacts with COX-1 up to 100 times more readily than with COX-2.