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Related to Cox-1: Cox-2


One of two isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins. It is present in cells throughout the body and is inhibited by NSAIDs.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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Noun1.Cox-1 - an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys; "an unfortunate side effect of NSAIDs is that they block Cox-1"
Cox, cyclooxygenase - either of two related enzymes that control the production of prostaglandins and are blocked by aspirin
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
COX-1 is present in most tissues and helps maintain the normal lining of the stomach as well as kidney and platelet function.
COX is a key enzyme that present two isoforms (COX-1 and COX-2), both of which act as rate-limiting enzymes in PG biosynthesis by metabolizing arachidonic acid.
COX-1 and COX-2, although they catalyze the same reaction but their properties are markedly dissimilar4.
NSAIDs work by inhibiting cyclooxygenase, COX-1 and COX-2, enzymes, which cause inflammation.
The COX-1 enzymes have been shown to play a protective role, whereas COX-2 enzymes have been associated with inflammation and pain.
Besides alcohol, platelet aggregation could be decreased by the inhibition of cyclooxygenase-1 (COX-1) activity by phenolic compounds present in wine, such as resveratrol [5].
The former "housekeeping" functions are attributed to the first of two established COX isoforms, the constitutively expressed COX-1, while the inflammatory response is associated largely with the inducible isoform, COX-2.
As enzimas COX sao encontradas em isoformas diferentes e sao codificadas por dois genes diferentes, sendo a COX-1 e a COX-3 codificadas pelo gene 1 da COX e a COX-2 codificada pelo gene 2.
Therefore, there is a need to define novel, nontoxic dietary constituents with proven chemopreventive effects through other pathways that also possess COX-2 but not COX-1 inhibitory activity.
The other, COX-1, works in platelets-cells in the blood that sticks together in the first stages of clotting.