Cox-2


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Related to Cox-2: Cox-1

COX-2

 (kŏks′to͞o′)
n.
One of two isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins. It is specifically induced at sites of inflammation and can be selectively inhibited by certain NSAIDs in order to reduce pain.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Cox-2 - an enzyme that makes prostaglandins that cause inflammation and pain and fever; "the beneficial effects of NSAIDs result from their ability to block Cox-2"
Cox, cyclooxygenase - either of two related enzymes that control the production of prostaglandins and are blocked by aspirin
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References in periodicals archive ?
The selective COX-2 inhibitors are known to be associated with an increased risk of death in patients with previous MI.[sup][2] In the present case, the prothrombotic effect of a selective COX-2 inhibitor might not be the main pathophysiology of MI.
In addition, correlations between miR-142-3p and Cox-2 as well as PI3K/AKT/mTOR pathways were detected to reveal the underling molecular mechanism in which miR-142-3p protected MLE-12 cells from bleomycin.
COX-2 is an inducible enzyme and produces prostaglandins in response to inflammatory stimulus or growth factors.
Enter COX-2. In the late 1990s, the first COX-2 selective NSAID was introduced, to inhibit inflammation-promoting COX-2.
We subsequently investigated whether MK801 (a NMDA receptor inhibitor), Dickkopf-1 (DKK-1, an inhibitor of the Wnt/[beta]-catenin pathway), NS-398 (a COX-2 inhibitor), and bevacizumab (IVB, a VEGF inhibitor) can modulate [beta]-catenin, COX-2, and VEGF expression levels and the neuronal loss in the retinas of the rats.
While remaining mammary tumors showed positive behavior of COX-2 gene expression, but it was down regulated as compared to normal samples included in the study with fold changes i.e.
Objective: To investigate the effects of varying Warfarin doses on IL-6 and COX-2.
This scientific communication has the goal to report COX-2 expression in seven canine epithelial neoplasms and adjuvant treatment with selective COX-2 inhibitors.
BRCA1 high grade negative expression and COX-2 positive gene expression were observed in this study.
All the samples were subjected to immunohistochemical assay to detect the expressions of COX-2, GLUT-1 and VEGF.
A recent analysis, published in the journal Rheumatology, found that the use of COX-2 inhibitors more than doubles the risk of venous thromboembolism (VTE)--the development of a blood clot in a deep vein that may then travels to the lung and form a pulmonary embolism.