When cell types that typically produce little or no COX-2
become cancerous, they often churn out excessive amounts of the enzyme, which stimulate the formation of blood vessels that feed a growing tumor.
The bad news is that in a review of the research on the COX-2
inhibitors, it seems they may have the same negative effect on kidney function as older NSAIDs, adversely affecting renal function, disturbing sodium and potassium balance, and impairing the work the kidneys do.
As an alternative to NSAIDs, the potential market for cox-2
inhibitors is enormous.
Vioxx was a widely used Cox-2
selective non-steroidal anti-inflammatory drug.
Moreover, acetaminophen doesn't seem to inhibit COX-1 or COX-2
Despite the negative publicity, the Pri-Med Institute survey found that three out of four primary care physicians believe that the COX-2
Inhibitor drug category remains an important option in treating severe chronic pain in patients who do not have pre-existing heart conditions or hypertension.
The work adds this malignancy to a list of tumors with a Cox-2
Examples of non-selective COX-2
inhibitors include products such as naproxen.
Unlike those drugs, APHS causes irreversible changes in COX-2
, permanently knocking out the enzyme.
about the cardiovascular safety of its COX-2
inhibitor Celebrex (celecoxib) based on an analysis of two long-term cancer trials.
Now, a study in rats shows that a recently developed anti-inflammatory drug, celecoxib, thwarts COX-2
but not COX-1, say scientists at the American Health Foundation, a nonprofit cancer research center in Valhalla, N.
If you are interested in a virtual brochure, which provides manufacturers, end-users and other industry participants an overview of the latest analysis of the Vioxx Recall: Revenue Analysis and Impact on Cox-2
Inhibitor Markets - then send an email to Danielle White - Corporate Communications at dwhite@frost.