Cox-2 inhibitor

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COX-2 inhibitor

Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
In general, one would expect the impact of Vioxx or Celebrex brand television DTCA to shorten the time that patients wait before initiating any COX-2 inhibitor treatment--in which case the parameter on the advertising measures will be negative and significant.
For this study, we were interested only in those recipients who were continuously taking either a COX-2 inhibitor, an NSAID, or other pain relieves throughout the 2-year study period.
Although we still have a COX-2 inhibitor option with the availability of celecoxib (Celebrex), there are two major impediments to its use.
To test whether thwarting COX-2 would have an effect on mice predisposed to pancreatic cancer, the researchers fed chow containing a COX-2 inhibitor called nimesulide to mice harboring the Kras mutation.
26 in the journal Circulation, the American Heart Association (AHA) cautions doctors about recommending the COX-2 inhibitor celecoxib (Celebrex), and other nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit this enzyme.
The journal Clinical Cancer Research has published research indicating that a component of green tea, combined with low doses of a COX-2 inhibitor, could slow the spread of prostate cancer.
The Food and Drug Administration has issued a nonapprovable letter for the COX-2 inhibitor etoricoxib (Arcoxia), according to the drug's manufacturer, Merck & Co.
Green tea alone reduced tumor growth by 42%, and the Cox-2 inhibitor celecoxib slowed it by 57% on its own, according to a study published in last week's issue of the journal Clinical Cancer Research.
Vioxx, a COX-2 inhibitor in anti-inflammatories, was banned in 2004 after it was shown that patients on the drug were more than twice as likely to have heart attacks as those not taking it.
Research has found that the Cox-2 inhibitor celecoxib, which is used to treat arthritis and acute pain, increases by more than twofold the risk of a heart attack.
withdrew its popular COX-2 inhibitor Vioxx from the global market last September after a study showed that it doubled patients' risk of heart attacks and strokes.