Cox-2 inhibitor

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COX-2 inhibitor

n.
Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
References in periodicals archive ?
Although COX-2 selectivity is a likely contributor to the higher CV risk seen with NSAID use, it is not the only factor, given that a higher CV risk has been seen with both coxibs as well as tNSAIDs.
It's well-known that COX-2 selectivity is generated by one amino acid substitution of isoleucine at position 523 in COX-1 with valine in COX-2, while the smaller Val523 residue in COX-2 opens up an 17% extra space, namely side pocket in the enzyme, which allows large molecules to pass into the entrance of COX-2 channel (Gierse et al.
Increasing degrees of COX-2 selectivity are associated with augmented cardiovascular risk.