Cox-2 inhibitor

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COX-2 inhibitor

Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Most typically, celecoxib is seen to possess a similar COX-2 selectivity ratio to diclofenac ([IC.sub.50] ratios of 30 and 29, respectively, is commonly cited) [7,8] with etoricoxib typically producing a ratio an order of magnitude higher in vitro [9].
Although COX-2 selectivity is a likely contributor to the higher CV risk seen with NSAID use, it is not the only factor, given that a higher CV risk has been seen with both coxibs as well as tNSAIDs.
From a chemical point of view, selective COX-2 inhibitors possess 1,2-diarylsubstitution on a central heterocyclic or carbocyclic ring system with a characteristic methanesulfonyl, sulfonamido, azido, methanesulfonamide, or pharmacophore-based tetrazole group on one of the aryl rings that play a crucial role on COX-2 selectivity. Etoricoxib, in particular, belongs to the 6-membered core group and, as other 1,2-diarylpyridine derivatives, it has shown good COX-2 inhibitor potency and selectivity.