Cox-2 inhibitor

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COX-2 inhibitor

Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.
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Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
References in periodicals archive ?
Indeed, the use of diclofenac (which has a ratio of COX1:COX2 inhibition similar to that of the COX2 inhibitor celebrex) is associated with increased cardiovascular risk, while the use of naproxen (which is a more selective COX1 inhibitor) is not (31).
Following this, an oral natural COX2 inhibitor was administered, which produced both anti-inflammatory and antianalgesic effects without gastric distress.
Our study shows that COX2 inhibitors do have an effect on the tumor cells,' said the study's first author William Guerrant from the Florida campus of The Scripps Research Institute (TSRI) in the US.
They compared the safety of non-steroidal anti-inflammatory drugs (NSAIDs) - such as ibuprofen, diclofenac and naproxen - with a newer class of more targeted drugs called COX2 inhibitors, which include celecoxib.
Specifically in Colombia, where the availability of new COXIBs in veterinary medicine is non-existent, as well as the variety of breeds and crossbreeds, makes the use of these specific COX2 inhibitors a new therapeutic alternative for canines with articular pain.