Cox-2 inhibitor

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COX-2 inhibitor

Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.
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Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
References in periodicals archive ?
High-Dimensional Versus Conventional Propensity Scores in a Comparative Effectiveness Study of Coxibs and Reduced Upper Gastrointestinal Complications.
Patients with osteoarthritis and arthritis should continue to consult their doctor before taking NSAIDs or coxibs and clinicians need to weigh the potential hazards of worsening blood pressure control when considering the use of these agents.
8%) each attributed to coxibs, aspirin and oxicams and 2 patients (7.
To address unanswered questions regarding CV risk of coxibs vs tNSAIDs, the FDA mandated a comparison of celecoxib with 2 tNSAIDs, ibuprofen and naproxen.
Cardiovascular risks of diclofenac and ibuprofen are comparable to those of coxibs (16, 17).
Final analysis showed that the vascular risks of high-dose diclofenac and possibly ibuprofen are similar to those of coxibs, but that high-dose naproxen is associated with less vascular risk than other NSAIDs (CNT Collaboration et al.
Both coxibs and nsNSAIDs have been associated with adverse cardiovascular outcomes such as myocardial infarction (BMJ 2005;330:1366), and rofecoxib was voluntarily withdrawn in 2004 by its manufacturer from the U.
Unless there is a contraindication, patients must receive a regimen based on a time scheme consisting of NSAIDs, COXIBs or acetaminophen and calcium-channel antagonists (gabapentin and pregabalina).
Low-dose aspirin, coxibs, and other NSAiDS: a clinical mosaic emerges.
The excess annual risk of upper gastrointestinal bleeding per 1,000 patients is about one with low-dose aspirin, about two with coxibs, and about four to six with traditional NSAIDs (ibuprofen, naproxen).