Cushing's disease

Also found in: Thesaurus, Medical, Acronyms, Encyclopedia, Wikipedia.
Related to Cushing's disease: Cushing's syndrome, cortisol, Addison's disease

Cush·ing disease

 (ko͝osh′ĭng) or Cush·ing's disease (-ĭngz)
A disorder caused by excess production of the hormone ACTH by a pituitary tumor, which results in the symptoms of Cushing syndrome.

[After Harvey Williams Cushing.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

Cushing's disease

(ˈkʊʃɪŋz) or

Cushing's syndrome

(Pathology) a rare condition caused by excess corticosteroid hormones in the body, characterized chiefly by obesity of the trunk and face, high blood pressure, fatigue, and loss of calcium from the bones
[C20: named after Harvey Williams Cushing]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

Cush′ing's disease`

a disorder of metabolism caused by overproduction of the hormone ACTH, resulting in hypertension, striated skin, accumulations of fat on the face and other areas, and other disturbances.
[1935–40; after H. W. Cushing, who first described it]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Cushing's disease - a glandular disorder caused by excessive ACTH resulting in greater than normal functioning of the adrenal gland; characterized by obesity
adenosis, gland disease, glandular disease, glandular disorder - a disorder of the glands of the body
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
The company is also developing oral nonpeptide somatostatin agonists for hyperinsulinism, as well as oral nonpeptide ACTH antagonists for the treatment of Cushing's disease. All of the company's drug candidates are new chemical entities resulting from in-house drug discovery efforts.
Ketoconazole was prescribed to 5 (5.1%) patients (3 Cushing's disease and 2 Ectopic Cushing's); Desmopressin, Propylthiouracil, and Sandostatin LAR were given to 1.0-3.1% patients individually (Figure-4).
Hyperadrenocorticism (Cushing's disease) can elevate glucose levels.
* Systemic disease: thyroid disease, irritable bowel disease (IBD), kidney failure, Cushing's disease, cancer
There are reports of dogs having both hypothyroidism and Cushing's disease but it is uncommon.
The rare disorder, known as Cushing's disease, is a serious condition that leads to an excess of the hormone cortisol in the body and affects just 10 to 15 people per million per year.
Lebrethon et al., "Cushing's disease in childhood: presentation, investigation, treatment and long-term outcome," Hormone Research in Paediatrics, vol.
Moreover, although rosiglitazone has been used as a therapeutic drug for the treatment of Cushing's disease due to its ability to reduce ACTH and corticosterone secretion in mouse corticotropic pituitary tumors, it has generally shown unsatisfactory results [21].
Colao, "The treatment of Cushing's disease," Endocrine Reviews, vol.
reported that surgery was beneficial in a 38-year-old pregnant woman with Cushing's disease recurrence.
Schteingart, "Elevated cortisol levels in Cushing's disease are associated with cognitive decrements," Psychosomatic Medicine, vol.