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1. A cell that has nuclear DNA from one source and cytoplasmic DNA from another, such as a nonhuman animal cell that has had its nucleus replaced by the nucleus of a human somatic cell.
2. A cell line or organism derived from a cybrid cell.

[Blend of cytoplasmic and hybrid.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Genetics) a hybrid cell, being a fusion of a whole cell with a cytoplasm, containing a nuclear genome from one source and a mitochondrial genome from another
[c21: from cy(toplasmic) + (hy)brid]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
The Leber's Hereditary Optic Neuropathy (LHON) osteosarcoma cytoplasmic hybrids (cybrids) were kindly gifted from Drs.
Other techniques to transfer the target cells of mitochondria, isolated beforehand, include formation of transmitochondrial cybrids [118] and the use of photothermal nanoblades [119] as well as the direct cell injection of mitochondria, as performed in oocytes [120-122].
We and others have used transmitochondrial cytoplasmic hybrids (cybrids) to investigate the effects of mtDNA haplogroups/SNPs on disease conditions in human cells.
Yi, "Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways," Experimental Gerontology, vol.
This entirely mutation-dependent reduction in energy supply is supported by studies using cybrids carrying LHON mutations as well as peripheral lymphocytes from patients and mutation carriers [13].
Moraes, "Human xenomitochondrial cybrids: cellular models of mitochondrial complex I deficiency," Journal of Biological Chemistry, vol.
Tumorigenicity and its suppression in cybrids of mouse and Chinese hamster cell lines.
Enhanced generation of mitochondrial reactive oxygen species in cybrids containing 4977-bp mitochondrial DNA deletion.
(49.) Ma Y, Bai RK, Trieu R, Wong LJ: Mitochondrial dysfunction in human breast cancer cells and their transmitochondrial cybrids. Biochim Biophys Acta.