Targeting cyclins and cyclin-dependent kinases
in cancer: lessons from mice, hopes for therapeutic applications in human.
Ruiling Zhang and team from Xinxiang Medical University explored the correlation between cyclin-dependent kinase
5 expression in the hippocampus and neurological impairments following prenatal ethanol exposure, and found that prenatal ethanol exposure could affect cyclin-dependent kinase
5 and its activator p35 in the hippocampus of offspring rats.
Western blotting was used to measure cyclin-dependent kinase
(CDK) inhibitors p21 and p27 that arrest cell cycle.
Real-time RT-PCR demonstrated that the expression of the cell cycle-driving molecule, cyclin-dependent kinase
4 (Cdk4), in HCC was significantly reduced by the treatments with vitamin K2, K3 and K5.
p27(KIP1) is a member of the CIP1/KIP1 family of cyclin-dependent kinase
inhibitors and is a potential tumor suppressor gene.
Some of the non-biological drugs, known as Cyclin-dependent kinase
(CDK) inhibitors, are currently being tested for use in cancer treatment.
Altered prostatic epithelial proliferation and apoptosis, prostatic development and serum testosterone in mice lacking cyclin-dependent kinase
inhibitors," Biology of Reproduction 73(5): 951-958.
STRUCTURAL STUDIES OF CYCLIN-DEPENDENT KINASE
INHIBITORS: DYNAMICS AND FLEXIBILITY ARE THE STORY.
The report provides a competitor evaluation in the field of synthetic molecules targeting polo-like kinase 1 (Plk-1), cyclin-dependent kinase
(CDK) or aurora kinase for treatment of cancer as of September 2011.
Verzenio is a cyclin-dependent kinase
(CDK)4 & 6 inhibitor that will be available as 50, 100, 150 and 200 mg tablets.
4] Genes: let-7; HRAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; NRAS, neuroblastoma RAS viral (v-ras) oncogene homolog; CCND2, cyclin D2; CDK6, cyclin-dependent kinase
6; CDC25, cell division cycle 25 homolog C (S.
Cip1, or Sdi 1) is the founding member of the Cip/Kip family of cyclin-dependent kinase
inhibitors, which also includes p27 (el-Deiry et al.