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Related to Cyclo-oxygenase: Cyclooxygenase 2 inhibitors


 (sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
1. See COX-1.
2. See COX-2.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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Noun1.cyclooxygenase - either of two related enzymes that control the production of prostaglandins and are blocked by aspirin
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
Cox-1, cyclooxygenase-1 - an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys; "an unfortunate side effect of NSAIDs is that they block Cox-1"
Cox-2, cyclooxygenase-2 - an enzyme that makes prostaglandins that cause inflammation and pain and fever; "the beneficial effects of NSAIDs result from their ability to block Cox-2"
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
(1) Nonsteroidal anti-inflammatory drugs (NSAIDs) work to decrease inflammation through the inhibition of cyclo-oxygenase (COX).
The primary objectives of the study were to: evaluate cyclo-oxygenase inhibition to inform the doses of ATB-346 to be used in part two, the upcoming dose-ranging, efficacy study; obtain a series of blood samples at distinct time intervals to facilitate analysis of the principal metabolites of ATB-346; and further assess the overall safety and tolerability of the drug.
It is reported that agents which produce reduction in carrageenan-induced edema, caused the inhibition of prostaglandins synthesis via inhibiting the cyclo-oxygenase (COX) enzyme (Skoutakis et al., 1988; Selvam and Jachak, 2004).
Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy.
activity of cyclo-oxygenase enzymes which normally lead to increased
The tripterpenoid cucurbitacin E is also present in watermelon, which provides anti-inflammatory support by blocking activity of cyclo-oxygenase enzymes which normally lead to increased inflammatory support.
(9) Raharjo and Fatchiyah also used molecular docking tools and Chimera 1.7s viewer software in a virtual screening of compounds from patchouli oil, concluding that alpha-patchouli alcohol is a potential inhibitor of the cyclo-oxygenase (COX)-l enzyme.
Phenyl butazone acts as NSAID by inhibiting prostaglandin synthesis by suppressing cyclo-oxygenase CO[X.sub.2] activity.
The effect of three cyclo-oxygenase inhibitors on intensity of primary dysmenorrhoeic pain.
The drug interferes with the activation of two forms of the cyclo-oxygenase (COX) enzyme in the body: COX-1 and COX-2.
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J 1995 Jan; 305(Pt 2):479-484.