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Related to Cycloxygenase: Cyclooxygenase 2 inhibitors


 (sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
1. See COX-1.
2. See COX-2.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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Noun1.cyclooxygenase - either of two related enzymes that control the production of prostaglandins and are blocked by aspirin
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
Cox-1, cyclooxygenase-1 - an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys; "an unfortunate side effect of NSAIDs is that they block Cox-1"
Cox-2, cyclooxygenase-2 - an enzyme that makes prostaglandins that cause inflammation and pain and fever; "the beneficial effects of NSAIDs result from their ability to block Cox-2"
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Aspirin inhibits the metabolism of arachadonic acid by irreversibly inhibiting cycloxygenase enzymes, preventing the production of prostaglandins.
Cycloxygenase 2 (Cox 2) inhibitors and/or bisphosphonates have shown some improvements.
However, the mechanism of immunosuppression in Entamoebiasis occur by induce macrophages eicosanoides in both Cycloxygenase and 5- Lipoxygenase pathway to produce prostaglandins and Leukotreins (16) which play important role in regulation of cellular and humoral immune response included the suppression of macrophages derived TNF-[alpha] and gene expression of interleukin-1 production and the MHC-II and other signal peptide necessary for cell-to cell communication would alter macrophage -lymphocyte driven reaction and down regulate the local immune response (17,18).
Liu, "Regulatory effect of herbs-partition moxibustion on cycloxygenase and prostaglandin E2 in ulcerative colitis rats at apoptosis directions," Journal of Clinical Rehabilitative Tissue Engineering Research, vol.
Our findings are similar to a study by Butz et al.14 CLA has anti-inflammatory properties via inhibiting of cycloxygenase (COX) and lipoxygenase (LOX) messenger ribonucleic acid (mRNA) expression and can bind to and activate the peroxisome proliferator-activated receptor gamma (PPARY).15-17 The decreased serum levels of TNF?
laevifrons, suggest a presence of two muscarinic receptors of high and low sensibility to acetylcholine and a coupled mechanism between muscarinic receptors and vasoconstriction mediated by cycloxygenase (Moraga and Urriola-Urriola, 2014).
Makheja et al., "Non-small cell lung cancer cycloxygenase activity and proliferation are inhibited by non-steroidal antiinflammatory drugs," Anticancer Research, vol.
The precursor, for PGs is arachidonic acid, which is metabolized by cycloxygenase (cox) enzymes resulting in its production.
There are many studies regarding the anti-inflammatory activity of plants is produced by phenolics and flavonoids as carvacrol, the flavones genkwarin and luteolin and the 6-hydroxy flavones cirsimaritin and salvigenin and polyphenolics as rosmarinic acid, and the monoterpenoid present in the essential oil: [alpha]-pinene (that inhibit the enzyme cycloxygenase and weak selectivity for eicosanoid, leukotriene B4 [LTB4] that was measured by radio immunoassay) and geraniol show weak selectivity for the thromboxane B2 [TXB2].