- Treatment-emergent Grade 3 or 4 cytopenias
including neutropenia (range, 19 to 29%), thrombocytopenia (range, 5 to 17%), and anemia (range, 0 to 9%) occurred in patients treated with IMBRUVICA[sup.
Patients suffer from autoimmune cytopenias
and rheumatoid arthritis (RA), which are thought to be mediated by LGL cells targeting host tissues.
Thereafter, haemophagocytosis and infiltration of organs by cytokine-activated histiocytes result in organomegaly, multiorgan dysfunction, life-threatening cytopenias
Signs and symptoms include hepatosplenomegaly, prolonged fever, cytopenias
, elevated triglycerides and elevated ferritin.
We also considered drug-induced cytopenias
, with lithium or pregabalin considered the most likely inciting substances.
Hematologic abnormalities, especially peripheral blood cytopenias
, are commonly noted in collagen vascular diseases (CVDs), including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), and may sometimes be the initial abnormality in the disease presentation.
MDS is a type of hematological malignancy, in which hematopoietic stem cells have disorders to produce sufficient normal blood cells, triggering cytopenias
Preclinical studies presented compelling evidence that Syk inhibition may have therapeutic value in the treatment of rheumatoid arthritis and other forms of arthritis, systemic lupus erythematosus, autoimmune cytopenias
, and allergic and autoinflammatory diseases.
5 2 factor Bone marrow <5 5--10 NA 11-- 21--30 blasts (%) 20 Karyotype Good Intermediate Poor NA NA Cytopenias
0/1 2/3 NA NA NA Median survival by age group (years) IPSS [greater >60 [greater than >70 classification than or (n=611) or equal (n=371) equal to]70(n=445) to]60 (n=205) Low (n=267) 11.
1) for their comments on our letter reporting an unusual case of fatal measles without rash in an immunocompetent woman who manifested cytopenias
and an intractable acute respiratory distress syndrome (2).
6,7) The cytopenias
may develop before the diagnosis of Sjogren's syndrome, and sicca symptoms may not be the predominant manifestation.
Traditional treatment strategies for immune cytopenias
include global immunosuppression that targets both the humoral and cell-mediated arms of the immune system.