Patients with MDS present with
cytopenias, or low blood cell counts.
Clinical assesment and management of
cytopenias in lupus patients.
The most common adverse events observed in clinical trials for Besponsa were
cytopenias, including febrile neutropenia.
The rate of serious adverse events was similar in the two groups, although grade 3 or greater adverse events, including treatment-related
cytopenias, were more common in the HSCT group, as was herpes zoster.
New or worsening grade 3 or 4 neutropenia, anemia and thrombocytopenia occurred mostly in patients with pre-existing
cytopenias.
Approximately two thirds of all patients with indolent T-LGL leukemia develop
cytopenias, recurrent bacterial infections, autoimmune disorders, and/or splenomegaly over the course of their disease.
Their ages ranged from 3 months to 10 years, male: female ratio was 2: 1, fever was present in 100% cases, splenomegaly in 100%,
cytopenias in two out of three cell lines in 100%, hypertriglyceridemia in 50%, hypofibrinogenemia in 50%, elevated ferritin in 66.
Fever, splenomegaly,
cytopenias in three cell lineages, increased ferritin, hypertriglyseridemia and hemophagocytosis in the bone marrow were observed.
Anemia could also be deemed as a forerunner of other hematological
cytopenias in an HIV-infected patient.
In terms of toxicities, lenalidomide therapy has a higher rate of Grade 3-4 grade
cytopenias, infection, deep-vein thrombosis, and diarrhea.
1) It is characterized by a primary extranodal involvement of medium-sized lymphoid cells, typically with sinusoidal infiltration of the liver, spleen, and bone marrow, which results in hepatosplenomegaly, peripheral blood
cytopenias, and other related systemic symptoms.
The marrow morphological characteristics are associated with peripheral blood
cytopenias of one ormore lineage: anemia, granulocytopenia or thrombocytopenia.
