cytotoxic T lymphocyte

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cytotoxic T lymphocyte

Any of a class of T cells that target and kill infected or cancerous cells by recognizing foreign or abnormal antigens displayed on the surface of those cells and then causing them to undergo apoptosis. Also called cytotoxic T cell, killer T cell.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

References in periodicals archive ?

Atara Biotherapeutics presented results showing that circulating EBV-targeted cytotoxic T lymphocyte precursors could serve as a biomarker of clinical response to tab-cel in patients with EBV-driven diseases.

Atara Biotherapeutics presents Tab-cel clinical biomarker results

Induction of a [CD8.sup.+] cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ help.

Correlation analyses of CpG island methylation of cluster of differentiation 4 protein with gene expression and T lymphocyte subpopulation traits

In LTNP an immune response seems to occur with specific CD4 and CD8 T cells that control disease progression, in particular with highly active HIV-specific cytotoxic T lymphocyte (CTL).

Non-polarized cytokine profile of a long-term non-progressor HIV infected patient

In the article titled "Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway" [1], there were errors in the title, Introduction, Materials and Methods, and the legend of Figure 2, which should be corrected as follows:

Corrigendum to "Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway"

In addition, cytotoxic T lymphocyte antigen 4-blocking monoclonal antibodies enhance immune activity by prolonging T-cell activation.

Cancer and immune response: old and new evidence for future challenges

I read the recent publication on cytotoxic T lymphocyte antigen-4 (CTLA-4) A49G polymorphism with a great interest (1).

CTLA-4 A49G polymorphism and autoimmune blood disease: a comment / CTLA-4 A49G polimorfizmi ve otoimmun kan hastaligi: bir yorum

In addition to stimulating B lymphocytes, Th2 cells suppress the cytotoxic T lymphocyte response, decreasing the robustness of cell-mediated immunity.

Emerging infections and pregnancy

Wicker of the University of Cambridge in England and her colleagues report that the presence of one variant of the gene corresponds with lowered production of the protein called cytotoxic T lymphocyte antigen-4 (CTLA-4).

One gene may underlie various immune diseases. (Upsetting a Delicate Balance)

The vaccinated animals had good CTL (cytotoxic T lymphocyte) response after infection, stable CD4+ counts (T-cell counts), and CD4+ T cells that responded specifically to the infecting virus.

Vaccine Advance: Monkeys Still Infected, But Protected from Illness

Acute rejection developed only in those with detectable levels of donor-specific cytotoxic T lymphocyte precursors before conversion.

Measuring donor-specific cytotoxic T cells helps identify patients who can reduce immunosuppressive medication

Diminished influenza A virus-specific MHC class I-restricted cytotoxic T lymphocyte activity among elderly persons.

Stress, immune function, and the older adult

According to the company, Cytotoxic T lymphocyte associated antigen 4 (CTLA-4), also known as CD152, is a transmembrane protein encoded by the CTLA-4 gene that can down-regulate the activity of T cells when binding with its ligands, B7.1 and B7.2, a pathway used by tumour cells to avoid T lymphocyte attack.