cytotoxic T cell

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cytotoxic T cell

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

killer T cell


n.
a killer cell that destroys target cells only when specifically activated by helper T cells.
Compare natural killer cell.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cytotoxic T cell - T cell with CD8 receptor that recognizes antigens on the surface of a virus-infected cell and binds to the infected cell and kill it
T cell, T lymphocyte - a small lymphocyte developed in the thymus; it orchestrates the immune system's response to infected or malignant cells
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
CD8+ cytotoxic T-lymphocytes, or CTLs, from peripheral blood samples from study patients with TNBC were measured using specifically designed NPS-specific dextramers in a flow cytometry-based assay in duplicate.
They activate immune cells, including macrophages, natural killer (NK) cells, antigen-specific cytotoxic T-lymphocytes, and more.
"An association has been demonstrated between chronic viral infection, malignancy, and up-regulation of programmed death receptor 1 (PD-1) on CD8+ cytotoxic T-lymphocytes," the authors wrote in Cancer Immunology Research.
Thus, based solely on images, the algorithm learned to predict what the genome might have revealed about the tumour immune infiltrate, in particular with respect to the presence of cytotoxic T-lymphocytes in the tumour, and it established a radiomic signature.
This has been explicated by several authors who analyzed the lymphoid inflammatory component in LELCB by the importance of the inflammatory infiltrate and cytotoxic T-lymphocytes reflecting the strong immune response against the tumor cells and potentiating the effect of chemotherapy and radiotherapy [10,11,15].
Immunophenotyping demonstrated an increase of CD8+ cytotoxic T-lymphocytes (clone C8/144B, 1:200, Dako Glostrup, Denmark) in predominantly CD3+ T-lymphocytes (clone LN10, ready to use, Leica Newcastle, United Kingdom) contingent.
Graves' disease (GD) is an autoimmune thyroid disease that involves [1, 2] autoreactivity against thyrocytes by antibodies, lytic granules released from cytotoxic T-lymphocytes (CTLs), and apoptosis and the inappropriate presence of death receptors that activate apoptotic pathways [3-5].