ASN100 is a combination of two fully human monoclonal antibodies that together neutralize the six cytotoxins
critical to S.
, the polyphenols inhibit cancer cells from mutating and induce "apoptosis" causing their natural death which, otherwise, is impossible without a medical intervention such as chemotherapy, radiation and surgery.
PCM-075, a highly-selective adenosine triphosphate competitive inhibitor of the serine/threonine polo-like-kinase 1 (PLK 1) enzyme that is over-expressed in multiple hematologic and solid tumor cancers, has demonstrated synergy in preclinical studies with over 10 chemotherapeutic and target agents used in hematologic and solid tumor cancers, including FLT3 and HDAC inhibitors, taxanes, and cytotoxins
Upon internalization of the ADC, the antibody-bound cytotoxins
are released intracellularly, leading to programmed tumor cell death.
Market Insights Antibody Drug Conjugates are monoclonal antibodies that are attached to biologically active drugs such as chemotherapeutic drugs, radioactive isotopes, cytokines or cytotoxins
via chemical linkers with liable bonds.
In regard to Antibody-Drug Conjugates (ADCs), Bayer is working on antibodies to recognize tumor-specific proteins on cancer cell surfaces, which after binding selectively to cancer cells, release cytotoxins
to kill tumor cells.
aureus by broadly neutralising the six cytotoxins
key to the pathogenesis of pneumonia.
cholerae and Helicobacter pylori are known for their ability to produce vacuolating cytotoxins
demonstrating the association between biological effects (vacuolation) and pathogenicity caused by these microorganisms.
Staphylococcus aureus is known to secrete virulence factors including cytotoxins
, superantigens, lipases, and proteases that activate inflammatory cells and can cause significant skin barrier dysfunction.
The company's novel Azymetric, AlbuCORE, and EFECT platforms, its Zymelink conjugation platform and cytotoxins
, and its proprietary ZymeCAD structure-guided protein engineering technology, enable the development of highly potent bi-specific antibodies, multivalent protein therapeutics, and antibody drug conjugates across a range of indications.
Our state-of-the-art cGMP facilities feature site segregation for Schedule II-V Controlled Substances, Animal Health, Hormonal Products, Penicillin Products, Cytotoxins
, and Potent Compounds.
is complex and it has been considered as a good source of short neurotoxins and several cytotoxins