(NASDAQ: CNCE) has reported positive results from two studies in its Phase 1 programme evaluating CTP-692, a novel deuterium-modified form of D-serine
being developed as an adjunctive treatment for schizophrenia, the company said.
Concert Pharmaceuticals reported results from two studies in its Phase 1 program evaluating CTP-692, a deuterium-modified form of D-serine
being developed as an adjunctive treatment for schizophrenia.
Within the central nervous system (CNS), serine has an important role as an excitatory neurotransmitter (as D-serine
, and also as a precursor for glycine), as well as a precursor for protein synthesis, folate metabolism, and phospholipid synthesis (3, 4).
Previous investigations have studied the role of D-serine
in the pathogenesis of AD (58-60).
Moreover, microglial activation under physiological conditions, in addition to promote the removal of noxious stimuli and the activation of reparative mechanisms, has also the potential of modifying D-serine
Among those were D-serine
as an add-on to second-generation antipsychotics; encenicline, an alpha-7 nicotinic acetylcholine receptor antagonist; pomaglumetad methionil, a selective agonist for glutamate receptor subtypes mGluR2 and mGluR3; and bitopertin, a glycine reuptake inhibitor.
NMDARs are regarded as coincidence detectors because of their ligand-gated and voltage-gated properties that its activation requires both binding of glutamate and coagonist (glycine or D-serine
) and postsynaptic depolarization.
damages proximal renal tubules in rats (72), (73).
In a recent large, multicenter study, low dosage D-serine
(~30 mg/kg/d) did not separate from placebo, (33) but an open-label study suggests increased efficacy with dosages >30 mg/kg/d.
Led by Jose Feijo, group leader at the Instituto Gulbenkian de Ciencia (IGC), Portugal, and professor at Lisbon University, this international team has now discovered that the oscillations of calcium ions in the growing pollen tubes of tobacco and the weed Arabidopsis are facilitated by channels called Glutamate receptors-like (GLRs), and that these channels are opened by, amongst other components, a rare aminoacid, D-serine
This increase in calcium triggers the release of an amino acid, D-serine
, into synapses of surrounding neurons.
Among them are the immuno-histo-chemical study of D-serine
, preparing a polyclonal antiserum against D-asparte, inducing muscle contraction in silkworm larva with D-glutamic acid, a primary study of the D-amino acid accumulation system, whether D-amino acids are prevalent among eukaryotes, evaluating their nutrition, and determining D-amino acids in food and beverages using gas chromatography.