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Abstract: P5-17-03Poster Session 5: "The 12-gene DCIS Score assay: Impact on radiation treatment (XRT) recommendations utility"Authors: Manders JB, Kuerer HM, Smith BD, McCluskey C, Farrar WB, Frazier TG, Li L, Leonard CE, Carter DL, Chawla S, Medeiros LE, Guenther JM, Castellini LE, Buchholz DJ, Mamounas EP, Wapnir IL, Horst KC, Chagpar A, Evans SB, Riker AI, Vali FS, Solin LJ, Jablon L, Recht A, Sharma R, Lu R, Sing AP, Hwang ES, White J.
DCIS affects 4,800 UK women a year and appears to be getting more common because it can be readily diagnosed by breast screening.
Based on recent studies in the New England Journal of Medicine and the BMJ, they used an overdiagnosis rate of 22% for the breast cancer estimate; the overdiagnosis rate of 86% for DCIS came from a 2004 study.
Data source: A phase II, double-blind, placebo-controlled study compared antiproliferative effects, breast tissue and plasma levels of 4-OHT, and coagulation parameters in 26 women with DCIS, randomized to daily treatment with 4-OHT gel applied to both breasts or oral tamoxifen, after 6-10 weeks of treatment, ending the day before surgical excision.
4) Tissue sampling from core biopsy may not adequately represent the entire lesion (5); foci of ADH or DCIS elsewhere in a papilloma may be missed at percutaneous biopsy.
Many women undergo surgery to remove the area of DCIS, together with a border of healthy tissue around it.
The natural history of untreated DCIS remains unknown because most individuals diagnosed with DCIS are treated by surgical excision.
Excisional biopsy diagnoses in upgraded cases included DCIS (2 of 6 cases; 33%), invasive lobular carcinoma (2 cases; 33%), invasive ductal carcinoma (1 case; 17%), and pleomorphic LCIS (1 case; 17%).
Head of DCIS, Kamal Abbass, was among those who spoke in the press conference.
She was offered a right mastectomy operation for extensive DCIS of her right breast.
By enabling data communication, DCIS will support more efficient procedures and flight profiles through services such as revised departure clearances, automation of routine clearances, Traffic Flow Management reroutes, automated transfer of communications, optimized profile descents, and trajectory-based operations.
Women who have DCIS have no way of knowing whether these tiny clumps of suspicious cells are the seedlings of a tumor.
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