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Triple DMARD combination for rheumatoid arthritis resistant to methotrexate and steroid combination: a single-center experience.
The study examined the issue of interruption of TNF[alpha] DMARD therapy and found no statistically significant difference in total complication rate (infectious and non-infectious) between the patients whose therapy was interrupted for [greater than or equal to] 5 drug half-lives versus those whose therapy was not interrupted or interrupted for a shorter amount of time prior to surgery.
Total health care costs for patients prescribed NSAIDs or DMARDs were lower than for patients who received no treatment (1.678 [euro] for NSAID, 1.780 [euro] for DMARD versus None 2.852 [euro]).
In a clinical study of iguratimod administered as a monotherapy in patients with rheumatoid arthritis, the agent demonstrated superiority over placebo and non-inferiority compared to an existing DMARD (salazosulfapyridine).
By 1 year, 40% of the patients had been treated with a DMARD, which was reflected in changes in HAQ scores: Among the 590 patients in the group with the lowest HAQ scores, the median swollen and tender joint count was one at baseline and none at year 1.
As an antiangiogenic agent, 2ME2 may represent a novel, non-immunologic, oral-delivery DMARD approach to treating rheumatoid arthritis.
"Rigel has developed a potentially new class of DMARD to complement and possibly replace some of the currently available agents," said Ernie Brahn, M.D., Professor of Medicine and Rheumatology Program Director at the UCLA School of Medicine.
We defined multiple traditional DMARD therapy as simultaneous treatment with MTX and at least one other traditional DMARD.
announced today that the United States Food and Drug Administration (FDA) has approved XELJANZ 5 mg twice daily (BID) and XELJANZ XR (tofacitinib) extended release 11 mg once daily (QD) for the treatment of adult patients with active psoriatic arthritis (PsA) who have had an inadequate response or intolerance to methotrexate or other disease-modifying antirheumatic drugs (DMARDs).
In a survey composed of 58 factors related to DMARD escalation, the most important reasons to escalate DMARDs for rheumatologists were swollen joint count, DAS28, their global assessment of RA, worsening of erosions, and deterioration of disease activity compared to disease activity three months before.
A TNF inhibitor is the first agent when treatment with an NSAID and a conventional synthetic DMARD fails to bring about remission or minimal disease activity because of its much longer track record of safety and efficacy, she said.
Methotrexate is Still the Gold Standard For over 30 years, low-dose weekly methotrexate has been used as an affordable, well-tolerated DMARD, which is effective in over 75% of patients with JIA.
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