According to the researchers at the University of North Carolina, the reason for this effect could be explained by DNA methylation
of genes in breast cancer tumours or peripheral blood.
They discovered that lower socioeconomic status is associated with levels of DNA methylation
(DNAm) -- a key epigenetic mark that has the potential to shape gene expression -- at more than 2,500 sites, across more than 1,500 genes.
Accordingly, recent studies have described a role for DNA methylation
in epigenetic effects during development and intragenerational responses to stress in oysters (Gavery & Roberts 2014, Olson & Roberts 2014, Gonzalez-Romero et al.
For the first time, the research team has identified specific locations called 'loci,' within a plant's chromosomes which impart disease resistance to their offspring, by undergoing a reversible biochemical modification known as DNA methylation
, in response to a pathogen attack.
Epigenetic modifications in the genome such as DNA methylation
have been suggested to play a role in the processes involved in cardiovascular diseases.
Clinical and experimental studies indicated that expression of DNA methyltransferases especially that of DNMT3B could contribute to aberrant DNA methylation
in CRC tumors (l9-21).
Epigenetic marks, such as DNA methylation
, undergo dynamic reprogramming during gametogenesis and early preimplantation of embryos (Feil and Fraga 2012; Reik 2007).
The tissue samples were used for multiple molecular analyses, which first of all revealed that the sleep loss condition resulted in a tissue-specific change in DNA methylation
, one form of mechanism that regulates gene expression.
Objective: The objective of the study was to summarize the role of DNA methylation
in the development and metastasis of uveal melanoma (UM).
, an important epigenetic modification of many eukaryotic genomes, is thought to play a major role in regulating transcription and/or translation of genes and the manifestation of metabolic traits .
In addition, the environmental influence via epigenetic mechanisms, particularly altered status of DNA methylation
, contributes to the environment-host interaction in the development of SSc [7, 8].