References in periodicals archive ?
Bultmann et al., "Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells," EMBO Reports, vol.
For example, reports revealed that phosphorylated p38 induces toxic injuries through mediating DNMT1, DNMT3a, and DNMT3b expressions [33, 34], while others documented that activated p38 represses the induction of DNMT1 [35, 36].
Furthermore, Dnmt1, Dntm3a, and Dnmt3b mRNA expression was not significantly altered with BPA exposure (Figure S6B).
In addition, Fang and colleagues recently demonstrated that high MAFG levels driven by BRAF (V600) recruit Bach1 as partner along with CHD8, a chromatin remodeling factor, and DNMT3B, a DNA methyltransferase, to trigger epigenetic silencing of genes frequently hypermethylated in melanoma and colorectal cancer .
DNA methylation is carried out by a family of DNA methyltransferase enzymes, which include DNMT1, DNMT3A, and DNMT3B. Figure 2 illustrates the structure of these genes.
The oligonucleotide sequences targeting DNMT1, DNMT3a, and DNMT3b are as follows: DNMT1 (A): 5'-GCCCAATGAGACTGACATCAA-3'; DNMT1 (B): 5'-GGAACCAAGCAAGAAGTGA-3'; DNMT3a (A): 5'-AGCGGGCAAAGAACAGAAG-3'; DNMT3a (B): 5'-CCAGATGTTCTTCGCTAATAA-3'; DNMT3b (A): 5'-CCTGTCATTGTTTGATGGCAT-3'; DNMT3b (B): 5'-CCATGCAACGATCTCTCAAAT-3'.
Donnarumma et al., "MiR221 promotes stemness of breast cancer cells by targeting DNMT3b," Oncotarget, vol.
COX1 upregulation was also induced by knockdown of methyltransferases DNMT1, DNMT3a, and DNMT3b. However, the precise role of the upregulation of COX1 in senescence remains to be elucidated.
Two hundred seventy-seven SNPs (single-nucleotide polymorphisms) within the range of 20 kb up- or downstream of the following genes were genotyped: DNMT1, DNMT3A, DNMT3B, DNMT3L, TET1, TET2, TET3, TDG using the Illumina HumanHap550, HumanHap550-Duo or Human610-Quad BeadChip microarrays as described previously (Torgerson et al.
The same authors also suggested that EBV infection induced aberrant CpG hypermethylation of several genes by upregulation of DNMT3b through LMP2A in EBV-positive AGS cells compared to EBV-negative AGS cells.
Compared with untreated cells, a significant and dose-dependent reduction in the expression of all three DNA methyltransferases (DNMT1, DNMT3A, DNMT3B) was detected after PEP exposure (Figure 4D).
The methylation at the 5'-methylcytosine is catalyzed by DNA methyltransferases (DNMTs), including DNMT1, DNMT3A, and DNMT3B (Bestor 2000; Chen and Li 2004).
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