Zhao et al., "Role of daphnetin
in rat severe acute pancreatitis through the regulation of TLR4/NF-[kappa]B signaling pathway activation," The American Journal of Chinese Medicine, vol.
Yinget al., "Daphnetin
attenuates microglial activation and proinflammatory factor production via multiple signaling pathways," International Immunopharmacology, vol.
Daphnetin (DAP, Figure 1), a coumarin derivative extracted from Daphne odora var., is a natural anti-inflammatory product [8, 9].
Effects of Daphnetin on the TLR4/NF-[kappa]B Signaling Pathway in MCAO/R Mice.
Daphnetin, a natural coumarin derivative isolated from the traditional Chinese medicinal herb Daphne odora var., has been reported to show anti-inflammatory properties [8, 9, 19].
Based on the wide distribution of coumarin derivatives in plant-based foods and beverages in the human diet, our objective was to evaluate both the antioxidant and intestinal anti-inflammatory activities of six coumarin derivatives of plant origin (scopoletin, scoparone, fraxetin, 4-methyl-umbeliferone, esculin and daphnetin) to verify if potential intestinal anti-inflammatory activity was related to antioxidant properties.
Results: Treatment with esculin, scoparone and daphnetin produced the best protective effects.
(2003) reported the molecular and biochemical characterization of a gene encoding a novel O-methyltransferase that catalyzes the methylation of daphnetin in winter rye (Secale cereale L., Gramineae, cv.
Daphnetin methylation by a novel O-methyltransferase is associated with cold acclimation and photosystem II excitation pressure in rye.
Intestinal absorption of daphnetin
by rats single pass perfusion in situ.
induced differentiation of human renal carcinoma cells and its mediation by p38 mitogen-activated protein kinase.
Natural products like esculetin, fraxetin, daphnetin
and other related coumarin derivatives are recognized as inhibitors of the lipoxygenase and cycloxygenase enzymic systems, and of neutrophil-dependent superoxide anion generation (Fylaktakidou et al.