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(diˈfɒs fər əˈleɪ ʃən)

1. the removal of a phosphate group from an organic compound.
2. the resulting state or condition.
[1930–35; de- + phosphoryl the radical PO + -ation]
References in periodicals archive ?
Activated SHP-1 down-modulates BCR signaling by dephosphorylating various BCR signaling molecules including SLP65/BLNK.
SHP2 also suppresses T-cell activity against growing tumors through regulation of the adaptive immune response by binding to PD-1 and dephosphorylating CD28 and the protein LCK.
If PP1 is suppressed, cycle protein RB cannot perform dephosphorylating, and then the block of G2/M appears.
Ponatinib induces apoptosis in imatinib-resistant human mast cells by dephosphorylating mutant D816V KIT and silencing betacatenin signaling.
The host laboratory has found that Ymr1, a phosphatase dephosphorylating phosphatidylinositol-3-phosphate, plays a key role in the regulation of autophagy.
By dephosphorylating the D3 position of PIP3, those authors proposed that PTEN antagonized the phosphatidylinositide 3-kinase (PI3K) pathway, a notion realized through the data reported by Stambolic et al.