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 (dĕs-vĕn′lə-făk′sēn, -sĭn)
A drug of the SNRI class, C16H25NO2, used to treat depression.

[des(methyl)-, having a methyl group removed (from des-, variant of de-) + venlafaxine.]


n desvenlafaxina
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Potential high-profile products include paliperidone for schizophrenia, desvenlafaxine for depression and vildagliptin for diabetes.
Desvenlafaxine is currently under active investigation for the alleviation of moderate to severe hot flashes and night sweats.
One case report of possible infant seizure; no other reported adverse events Venlafaxine, Higher levels of desvenlafaxine than venlafaxine desvenlafaxine found in breast milk.
One strategy to help remember a list of antidepressants with a relatively low potential for CYP450 drug interactions is to use the mnemonic Various Medicines Definitely Commingle Very Easily (VMDCVE) to recall venlafaxine, mirtazapine, desvenlafaxine, (2) citalopram, vilazodone, (3) and escitalopram.
Despite successive courses of fluoxetine, desvenlafaxine, and bupropion, he continues to experience fatigue, feelings of worthlessness, and depressed mood.
Studies have shown in a cellular model that venlafaxine, but not desvenlafaxine, is an inducer of P-glycoprotein
According to American Psychiatric Association practice guidelines for treatment of MDD, depressed breast cancer patients who receive tamoxifen generally should be treated with an antidepressant that has minimal effect on CYP2D6 metabolism, such as citalopram, escitalopram, venlafaxine, or desvenlafaxine.
Consider using antidepressants that have at least 1 positive randomized controlled trial in bipolar disorder and low risk for mood destabilization (bupropion, (12), (14) sertraline, (14) fluoxetine, (4), (5) tranylcy-promine, (3), (28) or venlafaxine in bipolar II depression (20)) before using those with reported increased risk for inducing mania or hypomania (TCAs (1), (2) or venlafaxine in bipolar I depression(14)), multiple negative controlled trials (paroxetine(12), (13)), or no controlled data in bipolar depression (citalopram, escitalopram, fluvoxarnine, mirtazapine, duloxetine, desvenlafaxine, nefazodone, and selegiline transdermal).
Selective norepinephrine reuptake inhibitors such as venlafaxine, desvenlafaxine, and duloxetine have demonstrated efficacy for VMS and depression.
DR MUZINA: I do not know for sure if the data support it, but I have seen the same sort of continuation phenomena with venlafaxine, the new desvenlafaxine, and duloxetine.