Resolution serves as a way of discriminating between enantiomers of coordination compounds and diastereoisomer
formation is the primary technique used [22-30].
ref.] medium Calculated calculated dr (b) anti : from MAD syn experimental dr (c) [%] M062X/6- Gas/neat 5 : 95 57 46.5 31g(d) Water 29 : 71 36 BH&HLYP/6- Gas/neat 10 : 90 10 9 31g(d) Water 37 : 63 8 B3LYP/6- Gas/neat 11 : 89 0 2 31G(d) Water 38 : 62 4 B3LYP/6- Gas/neat 9 : 91 20 18 31G(d,p) Water 35 : 65 16 B3LYP/6-311 Gas/neat 16 : 84 54 33 ++G(3d,3p) Water 36 : 64 12 BH&HLYP/ Gas/neat 9 : 91 20 12 cc-pVDZ Water 40 : 60 4 (a) Diastereoisomer
ratio of anti to syn isomers as indicated by NMR analysis.
Bioassay-guided isolation of diastereoisomer
of kolavenol from Entada abyssinica active on Trypanosome brucei rhodesience.
Intravenous (IV) quinine (a 4-quinoline methanol) has been the mainstay of treatment for severe falciparum malaria, although in some countries, including the United States, quinidine, the dextrorotatory diastereoisomer
of quinine, is 2 used because of the non-availability of IV quinine .
The majority diastereoisomer
was isolated by TLC in 55 % yield.
48), satellites at 20,000 km (cf., m) above the Earth (p.70) and isoleucine being termed an enantiomer rather than correctly a diastereoisomer
For example, a chiral sulfoxide synthesis, the sulfoxidation of methyl cysteine methyl ester, has produced more than a 95% yield of one specific diastereoisomer
by adjusting the density of the [CO.sub.2], a result which could not be achieved in organic solvent media.
These have been characterized by Falk, McInnes, Walter and Wright as the C6' diastereoisomer
as well as the geometrical isomers of domoic acid, which are more conveniently obtained by photolysis of domoic acid.
This design is based on non-cycling of rings (B and C) of estradiol with special emphasis on configuration that is superior estrogenic activity with diastereoisomer
E, less with diastereoisomer
Z and furthermore, reduced activity with dihydrogenated compound.
[sup.1]H NMR and GC-MS analyses of the tetrahydroquinoline products showed that the structure of the unique diastereoisomer
3 and 4 detected was a cis-(2e, 4e) configuration.
(1) Silibinin is a diastereoisomer
pair of the A compound with 2R, 3R, 2'S, 3'R absolute configuration and the B-compound with the 2R, 3R, 2'S, 3'S configuration.
The chromatographic elution order of the amide derivatives was determined by derivatization of the individual enantiomers, and the diastereoisomer
of configuration R-amine-S-MTP eluted before that of S-amine-S-MTP in each of the three cases in which the individual analyte enantiomers were available, i.e., MDMA, MDA, and amphetamine.