diiodotyrosine


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Related to diiodotyrosine: Monoiodotyrosine

di`i`o`do`tyr´o`sine


n.1.(Chem., Med.) a chemical substance consisting of tyrosine with two hydrogen atoms on the benzene ring replaced by iodine atoms.
References in periodicals archive ?
Thyroglobulin contains 140 tyrosine residues and serves as the matrix to which reactive iodine is attached to form monoiodotyrosine (MIT) and diiodotyrosine (DIT).
The tyrosines are iodinated at one (monoiodotyrosine) or two (diiodotyrosine) sites and then coupled to form the active thyroid hormones, tetraiodothyronine or thryoxine ([T.sub.4]) and triiodothyronine ([T.sub.3]).
Thyroid peroxidase first oxidizes iodide to iodine and then iodinates tyrosines on thyroglobulin to produce monoiodotyrosine and diiodotyrosine. Thyroid peroxidase finally links two iodinated tyrosines to produce [T.sub.4] and [T.sub.3].