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Scientists found that ebselen, a drug which was discovered in the 1980s and has been investigated as a potential treatment for a variety of nervous system disorders, can effectively restore several important steps in the SOD1 assembly process including folding, dimerisation, and zinc binding.
The unpaired electron delocalises over the molecule entirely, and the molecules will not undergo dimerisation similar to majority of free radicals.
Chekkat et al., "Thioether analogues of disulfide-bridged cyclic peptides targeting death receptor 5: conformational analysis, dimerisation and consequences for receptor activation," ChemBioChem, vol.
IL-33 does not form a heterodimer complex with ST2 directly, but rather IL-33 signalling is initiated through the recruitment of an accessory and a coreceptor protein, IL-1R accessory protein (IL1-RAcP), which is necessary to induce ligand-based signalling activation via the dimerisation of both ST2 and IL1-RAcP [29].
The interaction between the IL-23 secreted by DCs and the corresponding receptor IL-12R[beta]1 in [CD4.sup.+] T cells induces receptor molecule dimerisation to approximate the receptor-coupled JAK kinase and cause activation through interactive tyrosine phosphorylation.
Under hypoxic conditions, prolyl hydroxylation is suppressed and the HIF [alpha]-subunit escapes proteasomal destruction, allowing translocation to the nucleus and dimerisation with HIF-1[beta] [17].
Nijenhuis [18] calculated the equilibrium constants of various candidates for the crosslinking reaction, showing that the crosslinks consist of two carboxylic acid anions coordinated with the dimerisation product of the Cr(III).
At the protein level activation of the MyD88-dependent pathway is suppressed by the synthetic inhibitor ST2825, which is a heptapeptide analog specifically designed to inhibit MyD88 dimerisation, thus interfering with the recruitment of IRAK1 and IRAK4 by MyD88 [93].
Furthermore, rather than the dimerisation as suggested by Holz-Schietinger et al.
GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: Effects on nitric oxide synthase activity, protein levels and dimerisation. Cardiovasc Res 2002;55:838-49.
These monomer subunits are bonded by disulphide-linkage by dimerisation, thus producing a 140-kDa dimer.