After combining with 1,25(OH)[sub]2D[sub]3, the nuclear-bound Vitamin D receptor dimerizes
with the retinoid X receptor, forming a joint complex.
with JUN to form AP-1, which regulates a class of genes involved in cell survival and death.
After ligand binding, AHR translocates to the nucleus, dimerizes
with its partner protein, aryl hydrocarbon receptor nuclear translocator (ARNT), and the AHR/ARNT-heterodimer binds to xenobiotic response elements (XREs), inducing gene expression for drug-metabolizing enzymes such as CYP1A1 and CYP1B1 (Beischlag et al.
A split Cre recombinase protein, which dimerizes
and is activated by blue light, will be used to genetically label cells (and their progeny) in a topologically defined manner ( compartment reporter ).
Thus, CTR dimerizes
with either of the RAMPs 1-3 to form receptors referred to as AMY1, AMY2 and AMY3.
Upon ligand binding, Kit dimerizes
, leading to autophosphorylation and downstream activation of the MAPK, PI3K-Akt, and JAK-STAT (janus kinase-signal transducer and activator of transcription) pathways.
Habener, "CHOP, a novel developmentally regulated nuclear protein that dimerizes
with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription," Genes and Development, vol.