Corynebacterium diphtheriae

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Noun1.Corynebacterium diphtheriae - a species of bacterium that causes diphtheria
corynebacterium - any species of the genus Corynebacterium
genus Corynebacterium - the type genus of the family Corynebacteriaceae which is widely distributed in nature; the best known are parasites and pathogens of humans and domestic animals
References in periodicals archive ?
ulcerans can become toxigenic through lysogeny by beta-corynebacteriophages harboring the diphtheria toxin gene.
CRM197 is a genetically detoxified diphtheria toxin.
Certain strains produce diphtheria toxin and can cause a serious condition similar to diphtheria infection (7).
The two commonly engineered bacterial toxins are Pseudomonas exotoxin (PE) and diphtheria toxin (DT).[sup][7] Both consist of three functional domains that can be produced as single polypeptide chains.
As discussed below, the engineered toxin components in the majority of the RITs are from either Pseudomonas exotoxin A (PE) or diphtheria toxin (DT) [16, 17].
E7777 is a fusion protein that combines the interleukin-2 receptor binding domain with diphtheria toxin fragments.
E7777 is a fusion protein that combines the interleukin-2 (IL-2) receptor binding domain with diphtheria toxin fragments.
Most of these complications are caused by diphtheria toxin which is a Polypeptide Exotoxin that enters the cell, inactivates Elongation Factor-2 and inhibits protein synthesis causing local tissue necrosis3.
These knock-in vectors consisted of NLS sequence, porcine [beta]-casein 5' arm (5.1 kb), human FGF2 or EGFP cDNA, SV40 polyA, neomycin resistance gene (neo) as a positive selectable marker gene, porcine Pcasein 3'arm (2.6 kb), and the diphtheria toxin A fragment (DT-A) gene as a negative selectable marker gene (Figure 1A).
Three examples of 3/10 helices that seem unstable may be found in the beta-structural (receptor-binding) domain of diphtheria toxin. In the 3D structure with 1SGK PDB identifier [22] those 3/10 helices can be found in three regions between two beta strands (see Figure 2).
In the other set, they interfered with the same neurons by eliminating them selectively during development using diphtheria toxin. The mice were given various non-invasive tests that measured how they respond to novelty, and anxiety, and how they react to cocaine.

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