a.1.(Mach.) Acting directly, as one part upon another, without the intervention of other working parts.
Direct-acting steam engine
one in which motion is transmitted to the crank without the intervention of a beam or lever; - also called direct-action steam engine.
Direct-acting steam pump
one in which the steam piston rod is directly connected with the pump rod; - also called direct-action steam pump.
Webster's Revised Unabridged Dictionary, published 1913 by G. & C. Merriam Co.
References in periodicals archive ?
SAN FRANCISCO -- The direct-acting anticoagulants, as a class, were more effective and at least as safe as warfarin in low-weight and very-low-weight patients with atrial fibrillation in an adjusted analysis of real-world outcomes data from more than 21,000 Korean patients.
Almost half of the women infected with HCV are unaware of their infection, and current treatment with direct-acting antiviral regimens is quite effective.
THIS STUDY PROVIDES "SUBSTANTIVE EVIDENCE" that curing hepatitis C virus with all-oral direct-acting antiviral regimeins provides clinical benefits, according to Raymond T.
Outcomes after successful direct-acting antiviral therapy for patients with chronic hepatitis C and decompensated cirrhosis.
Gilead Sciences announced that Japan's Ministry of Health, Labour and Welfare, or MHLW, has approved Epclusa, a once-daily treatment for adults with chronic hepatitis C virus, or HCV, infection with decompensated cirrhosis, and for patients with chronic HCV infection without cirrhosis or with compensated cirrhosis who have had prior treatment with a direct-acting antiviral therapy, or DAA.
TUESDAY, March 6, 2018 (HealthDay News) -- Direct-acting antiviral prophylaxis is safe and prevents chronic hepatitis C virus (HCV) infection after kidney transplantation from HCV-infected donors to noninfected recipients, according to a study published online March 6 in the Annals of Internal Medicine.
Improving access to DAA (Direct-Acting Antivirals) will happen by acquiring larger amounts of drugs at reduced costs and prescribing to earlier stages of HCV3.
Aviragen Therapeutics, a company engaged in the discovery and development of direct-acting antivirals to treat infections with limited therapeutic options, has signed a merger agreement with Vaxart, a clinical-stage company focused on developing oral recombinant vaccines, it was reported yesterday.
The company said Vosevi marks the latest single-tablet regimen in its portfolio of sofosbuvir-based, direct-acting antiviral treatments that offer people living with HCV a short course of therapy.
The drugs, called direct-acting antivirals, are close to 95 percent effective.
As of May 2016, only eight of the 3,487 Tennessee inmates who were diagnosed as having HCV had received treatment (the department also acknowledges that the actual number of inmates infected may be closer to 10,000.) A twelve-week regimen of direct-acting anti-viral drugs is the medically accepted standard of care and results in curing the disease in 90 percent of cases.

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