The summary data for both disopyramide
and sotalol each reflected only one relatively small trial.
To examine potential interferences, the following drugs were added to a whole-blood sample containing 5 mg/L PSC and CsD: acetaminophen (164 mg/L), amikacin (29 mg/L), amitryptyline (470 [micro]g/L), chloramphenicol (55 mg/L), CsA (360 [micro]g/L), digoxin (2.3 [micro]g/L), disopyramide
(5.2 mg/L), ethosuximide (108 mg/L), gentamicin (6 mg/L), lidocaine (6.5 mg/L), methotrexate (8 [micro]mol/L), phenobarbital (35 mg/L), phenytoin (22 mg/L), primidone (10.1 mg/L), procainamide (8.9 mg/L), N-acetylprocainamide (10.5 mg/L), propanolol (128 [micro]g/L), quinidine (4.7 mg/L), salicylate (330 mg/L), theophylline (24.07 mg/L), tobramycin (7.3 mg/L), valproic acid (105 mg/L), and vancomycin (36 mg/L).
did not reduce the mean resting heart rate from baseline, The combination of diltiazem and digoxin reduced the mean resting heart rate to a greater degree than the combination of propranolol and digoxin, but all 3 drags together were even more effective. That study also demonstrated that with exercise the combination of propranolol and digoxin was more efficacious for heart rate control than diltiazem and digoxin and that the 3-drug combination was not better than just propranolol and digoxin.
Interacting Drug Comments Antiarrhythmic Rifampin appears to substantially enhance the agents metabolism of several antiarrhythmic drugs such as disopyramide
, mexiletine, propafenone, quinidine, and tocainide.
Unlike procainamide, quinidine, and disopyramide
, flecainide rarely produces gastrointestinal effects.[11,13]
Poisoning due to class IA antiarrhythmic drugs: Quinidine, procainamide and disopyramide
. Drug Saf 5, 393-420.
Since the patient tolerated beta blockers and was doing fine with good symptomatic improvement in NYHA class, calcium channel blockers and disopyramide
were not considered.
and quinidine bind with inverse selectivity to muscarinic receptors in cardiac and extra cardiac rat tissues," Journal of Cardiovascular Pharmacology, vol.
Abdellatef, "Extractive-spectrophotometric determination of disopyramide
and irbesartan in their pharmaceutical formulation," Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol.
In cases of obstruction at rest, disopyramide
has been shown to be effective short-term, but long-term studies reveal that its clinical benefits decrease over time and its use is deterred by its significant anticholinergic side effects .
These tests are performed by administering sodium channel blockers to patients, such as flecainide, ajmaline, procainamide, propafenone and disopyramide
, while recording the changes in the ECG.
Patients randomized to the antiarrhythmic drug arm of the study received treatment with one of six eligible drugs: amiodarone, disopyramide
, dronedarone, flecainide, propafenone, or sotalol.