Formation and transfer of disulphide
bonds in living cells.
Serum total thiol estimation therefore provides measurement of the in vivo redox state, as thiols combat with free radicals to form disulphide
. Decreased total thiol levels have been documented in various diseases like diabetes mellitus, neurological diseases, cardiovascular diseases and kidney diseases.
Objective: To investigate novel oxidative stress marker thiol disulphide
homeostasis in patients with acute myocardial infarction.
Using direct current-voltage methods and few-layered 2D molybdenum disulphide
(MoS2) sheets, they produced cell signals two orders of magnitude higher than previous electrical-based detection methods.
Reactive oxygen species (ROS) forming in an organism cause oxidation and form disulphide
bonds by transferring excess electrons to thiols.
The first test system will be a disulphide
mediated protein folding enzyme from Mycobacterium tuberculosis.
Thiol consists of a sulfhydryl group, and under conditions of OS these functional groups form reversible disulphide
Formation of gluten network during mixing is enabled through inter- and intramolecular cross linking within monomeric gliadin fractions and within and between glutenin polymers, formed as a consequence of interchange reactions between sulphydryl groups (SH) and disulphide
bonds (SS) [1, 2].
(24, 47, 48) Mutation of Cys616 and Cys621 in rat TRPV1, which are located in the pore-forming domain between the fifth and sixth transmembrane regions, caused significant suppression of the TRPV1 activation by reactive disulphide
, NO and [H.sub.2][O.sub.2].
 The plasma thiol pool is mainly formed by albumin and protein thiols and slightly formed by low molecular weight thiols.12 Thiols can undergo oxidation reaction via oxidants and form disulphide
Atkin, "Novel roles for protein disulphide
isomerase in disease states: a double edged sword?" Frontiers in Cell and Developmental Biology, vol.
The incident at the Hindustan Insecticide Ltd (HIL) plant occurred while unloading carbon disulphide
. In the process of unloading the consignment of carbon disulphide
, the gas leaked, leading to the fire.