"The identification of the dorsal striatum
and habitual behaviour as a driver of addiction may allow the development of more specific treatment approaches to increase treatment success," said Xinqi Zhou, first author of the study.
These dopaminergic neurons are situated in the nigrostriatal pathway, which is a brain circuit that connects neurons in the substantia nigra pars compacta with the dorsal striatum
No significant group differences were found in the volume of the dorsal striatum
, but there were significant differences between hemispheres (p <0.05 ).
This potentiated reward correlated with response in areas of the brain that are critical for reward valuation, including the dorsal striatum
and mediodorsal thalamus.
These included the hypothalamus, amygdala, dorsal striatum
, insula, and anterior cingulate cortex.
The basal ganglia are a group of subcortical gray nuclei, which include the dorsal striatum
[i.e., caudate nucleus (CAU) and putamen (PUT)], ventral striatum [including the nucleus accumbens (NA)], globus pallidus (GP), substantia nigra (SN), and subthalamic nucleus (STN), and have complex anatomical and functional projections in the brain (1,2).
Restoring dopamine production in the dorsal striatum
reinstates feeding on regular chow, whereas restoration of dopamine production in the NAcc reinstates motivational behavior.
Bonsi, "The neurobiological bases of autism spectrum disorders: the R451C-neuroligin 3 mutation hampers the expression of long-term synaptic depression in the dorsal striatum
," The European Journal of Neuroscience, vol.
Those findings also corroborate the association found between the activation of DRD2/DRD3 in the dorsal striatum
and the ratings of the sensory/affective aspects of experimental pain, in healthy volunteers .
The circuits involve the ventral striatum, the orbitofrontal cortex, the amygdala, the dorsal striatum
, and the prefrontal cortex.
Endogenous dopamine regulates the rhythm of expression of the clock protein PER2 in the rat dorsal striatum
via daily activation of D2 dopamine receptors.