Down syndrome

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Related to Down's: trisomy 21, Down's process

Down syndrome

 (doun) or Down's syndrome (dounz)
A congenital disorder caused by the presence of an extra 21st chromosome and marked usually by moderate to severe intellectual disabilities, short stature, and a flattened facial profile. Also called trisomy 21.

[After John Langdon Haydon Down (1828-1896), British physician.]


(or Down's′) syn′drome

a genetic disorder associated with the presence of an extra chromosome 21, characterized by mental retardation, weak muscle tone, and epicanthic folds at the eyelids.
Formerly, mongolism. Also called trisomy 21.
[1960–65; after John Latin. H. Down (1828–96), British physician]

Down syndrome

A congenital disorder caused by the presence of an extra 21st chromosome. People with Down syndrome have mild to moderate mental retardation, short stature, and a flattened facial profile.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Down syndrome - a congenital disorder caused by having an extra 21st chromosomeDown syndrome - a congenital disorder caused by having an extra 21st chromosome; results in a flat face and short stature and mental retardation
trisomy - chrosomal abnormality in which there is one more than the normal number of chromosomes in a cell
síndrome de Down
Downin oireyhtymäDownin syndroomamongolismimongoloidismi
syndrome de Down
sindrom Down
downsyndroommongolismesyndroom van Down
Downs syndrom

Down syn·drome

n. síndrome de Down, anormalidad citogenética del cromosoma 21 caracterizada por retraso mental y facciones mongoloides.
References in periodicals archive ?
Susy was thirty-two-years old, a Down's Syndrome child.
Seven months after Susy's death, Marie's youngest sister Jeanne gave birth to a Down's Syndrome girl.
Jim Trent, director of eating disorders at Vanderbilt University's counseling center, welcomes Weigh Down's approach.
Older mothers are known to face a greater risk than younger women of giving birth to a baby with Down's syndrome, a genetic disorder characterized by mental retardation.
Antonarakis of Johns Hopkins University in Baltimore headed an international team of 18 other researchers that determined the extra chromosome responsible for Down's is incorporated more often during the first of the human egg's two stages of meiotic development.
One hundred percent of Zero Down's brokers have access to their loan files within the company's automated loan management center, U-CLOSE, via the Advectis(R) BlitzDocs(R) solution.
A new scientific report supports previous research indicating that cell therapy, a controversial treatment unlicensed by the federal government, provides no benefit to children with Down's syndrome, a genetic disorder that afflicts about one out of every 800 infants born in the United States.
A West German physicians, Franz Schmid, then at Heidelberg University, carried that work one step further in the 1960s by giving children with Down's syndrome subcutaneous or intramuscular injections of a preparation containing freeze-dried fetal sheep or rabbit cells.
Zero Down's loan programs are intended to provide homebuyers with flexibility during a market with rising housing costs and interest rates.
Zero Down's U-CLOSE automated loan management system delivers instant quotes, automated loan underwriting and real time loan status.
On the surface, Down's syndrome with its mental retardation and Alzheimer's disease with its mental regression appear to be linked only by the personal tragedies they create.
Down's syndrome, or trisomy 21, is a chromosomal anomaly leading to lower-than-normal mental ability, increased susceptibility to infections and higher incidence of leukemia, as well as to characteristic slanted eyes and skeletal abnormalities.