downregulation

(redirected from Down-regulation)
Also found in: Medical.
Related to Down-regulation: Upregulation, Up-regulation

downregulation

(ˌdaʊnrɛɡjʊˈleɪʃən)
n
(Medicine) a decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces
References in periodicals archive ?
Tie2 is an important regulator of vascular stability and its down-regulation is found in patients with diabetes and other conditions.
As observed previously, the DerGPG70 conjugate modulated disease through up-regulation of Th2, and down-regulation of Th1 and Th17 responses.
The EFECT platform is a library of antibody Fc modifications engineered to modulate the activity of the antibody-mediated immune response, which includes both the up- and down-regulation of effector functions.
However, this capability is lost in many tumour types due to the down-regulation of the ASS1 enzyme required for arginine production.
The expression of CD16 on NK cells can undergo considerable down-regulation in cancer patients, which significantly inhibits the immune system's antitumor response.
MTUS1/ATIP3a down-regulation is demonstrated in human salivary adenoid cystic carcinoma, and it plays an important role in cell proliferation, migration and invasion [19].
In contrast, 23(38.3%) subjects in Group I, 35(58.3%) in Group II and 45(75.0%) in Group III showed down-regulation (p 70 years (n=13)###6(46.2%)###7(53.8%)
These methods will allow us to determine if these AgP patients experience a down-regulation in loricrin.
The study results suggest that rIL-10 mediated down-regulation of hspX expression, in the presence of low concentration of rIFN-[gamma], could be used as an important strategy to decrease the dormancy of MTB in its host and thus making MTB susceptible to the standard anti-mycobacterial therapy used for treating tuberculosis.
The maximum down-regulation of badh2 gene (-12.20 +- 0.01 fold), the highest concentration of 2AP (0.14 +- 0.02 ppm) and the excellent phenotypic aroma score (score 4) was also observed at 25degC temperature.
FAMLF down-regulation by miR-181b inhibited cell viability and arrested cell cycle in Raji cells