Dry AMD refers to atrophy of the retina that occurs from the formation of drusen
, waste products that form deposits underneath the retina.
These deposits, called drusen
, are specifically found beneath a layer of retinal pigment epithelium (RPE) cells, which are known to be key players in macular degeneration.
In a study seeking to answer the question of whether all retinal nerve fiber layer (RNFL) defects are glaucomatous, Gur Gungor and Akman reassessed patients initially diagnosed with glaucoma based on RNFL damage detected on OCT and found that the ocular findings of some of those patients were actually due to different conditions such as ischemic optic neuropathy, optic neuritis associated with multiple sclerosis, optic disc drusen
, and pseudotumor cerebri.
sup] The vast majority of AMD patients have the dry form of the disease, characterized by a constellation of clinical features, including drusen
, pigment abnormalities (focal hyper- or hypopigmentation of the retinal pigment epithelium [RPE]), and GA of the macula.
were observed in all AMD patients whereas large drusen
were observed in 80(88.
She has a lazy eye and optic disc drusen
- a condition where the optic nerves gather calcium deposits.
Current high resolution optical coherence tomography devices provide ample new information on retinal layers, drusen
characteristics and their interaction.
Atrophic "dry" AMD, a breakdown of the macula in which yellow deposits known as drusen
themselves don't seem to cause blindness, but as they increase, your risk of developing advanced dry macular degeneration or the more serious, wet form of the disease increases.
Some 4203 individuals (mean age, 73 years) participating in the Age-Related Eye Disease Study 2 (AREDS2), who were at risk of progression to advanced age-related macular degeneration (because of the presence of bilateral large drusen
or large drusen
in 1 eye and advanced macular degeneration in the other eye), were randomly assigned to receive, in double-blind fashion, daily supplementation with lutein (10 mg) plus zeaxanthin (2 mg), omega-3 fatty acids (650 mg of EPA and 350 mg of DHA), both treatments, or placebo.
The oxidation ofpolyunsaturated fats in the retina leads to lipid peroxidation products such as carboxyethylpyrrole and 4-hydroxy-2-nonenal, which can form adducts with proteins and accumulate in the outer retina and in drusen
I diagnosed drusen
which can be a precursor to age-related macular degeneration.