Duchenne muscular dystrophy


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Related to Duchenne muscular dystrophy: Becker muscular dystrophy

Du·chenne muscular dystrophy

 (do͞o-shĕn′)
n.
A severe form of muscular dystrophy that begins in early childhood and almost exclusively affects males, characterized by progressive weakening of the muscles and usually leading to death from respiratory or cardiac failure. It is caused by lack of the protein dystrophin in muscle cells as a result of a recessive genetic mutation on the X chromosome.

[After Guillaume B.A. Duchenne (1806-1875), French physician.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
Release date- 27082019 - Pratteln - Santhera Pharmaceuticals (SIX: SANN) announces publication by ReveraGen of positive study data with vamorolone in patients with Duchenne muscular dystrophy (DMD).
The "Duchenne Muscular Dystrophy Drugs - Market Analysis, Trends, and Forecasts" report has been added to ResearchAndMarkets.com's offering.
The company said EMFLAZA (deflazacort) is now indicated for the treatment of Duchenne muscular dystrophy in patients two years of age and older.
They restored muscle stem cell function that is impaired in Duchenne muscular dystrophy, resulting in efficient regeneration of the muscle and preventing the progressive loss of muscle strength characteristic of the disease.
St Margaret's headteacher Paul Nugent said:"Somhairle battles with Duchenne Muscular Dystrophy every day and is an integral part of the St Margaret's Primary School family.
A previous clinical trial, the HOPE-Duchenne trial, found a single intracoronary dose of CAP-1002 was generally safe, well tolerated and demonstrated significant and sustained signals of improvement in cardiac and skeletal muscle function in boys and young men in advanced stages of Duchenne muscular dystrophy.
To find out more about Duchenne Muscular Dystrophy and Alex's Wish visit www.alexswish.co.uk
The mum went back to the doctors and tests were carried out, which confirmed he had Duchenne Muscular Dystrophy. Ty is now on medication.
People with Duchenne muscular dystrophy are unable to produce a protein known as dystrophin that is needed by the cells of the muscles.
Duchenne muscular dystrophy interrupts the oro-facial function and brings the difficulties in the pre-oral phase of swallowing.12 The bite force and mouth opening distance in these patients are considerably lower than maximum.13 Macroglossia, tongue propelling, mouth breathing and lip incompetency commonly seen in DMD patients.14 Mandibular elevator muscles are rotated downward and backward because of progressive weakness thus leading to turning of the mandible away from the maxilla resulting in long face deformity with open bite.11
CureDuchenne Ventures collaborates with pharmaceutical and biotechnology companies to facilitate the development of drugs to treat Duchenne muscular dystrophy.