Zollner et al., "Quality of life in Parkinson's disease patients with motor fluctuations and dyskinesias
in five European countries," Parkinsonism and Related Disorders, vol.
Tardive hyperkinesias are also called Tardive dyskinesias
, are isolated involuntary dyskinesia
mainly developing in the orofacial region.
Gardos et al (4) described 2 other forms of delayed dyskinesias
related to antipsychotic use but resulting from antipsychotic discontinuation: withdrawal dyskinesia
and covert dyskinesia
Extrapyramidal side effects include early onset dyskinesias
, such as dystonias (twisting of the neck or facial spasms); akathisia (inner restlessness with inability to sit still); and Parkinsonian symptoms (bradykinesia, pill-rolling tremor or shuffling gait); and late onset dyskinesias
, such as tardive dyskinesia
(irregular jerking movements of the face and extremities) and dystonia.
Kartagener syndrome is part of the larger group of disorders referred to as primary ciliary dyskinesias
. Approximately one half of patients with primary ciliary dyskinesia
have situs inversus and, thus, areclassified as having Kartagener syndrome.
10 June 2011 - US Abbott (NYSE: ABT) said on Thursday that interim efficacy and safety results from a long-term, 54-week, Phase III open-label study of its investigational treatment for advanced Parkinson's disease showed that patients treated with levodopa-carbidopa intestinal gel (LCIG) for 12 weeks reported a decrease in "off" time and an increase in "on" time without troublesome dyskinesias
By the final visit, dyskinesias
were more common in the initial levodopa group than in the initial pramipexole group (37% vs.
8 October 2009 - Danish biopharma company NeuroSearch A/S (CPH: NEUR) said today that it initiated a phase Ib clinical study of its ACR325 candidate drug for treatment of dyskinesias
in Parkinson's disease.
Frequently associated with motor fluctuations are abnormal movements typically related to the use of dopamine and often termed dopamine-induced dyskinesias
. These may be very complex in terms of the type of movement seen and the relationship to dopamine levels, and some of the commonest types are directly related to dopamine levels peaking in the brain.
Neurotoxicity associated with neuroleptic-induced oral dyskinesias
improved (to some extent) in all patients after amantadine treatment, only 73.3% experienced improvement of motor symptoms.
He is the only patient at Puget Sound Neurology ever to develop rhabdomyolysis due to dyskinesias
. Following bilateral subthalamic nucleus deep brain stimulation, his Parkinson's symptoms have improved dramatically, and his motor complications are significantly improved.