MiR-141 is a key regulator of renal cell carcinoma proliferation and metastasis by controlling ephA2
Besides ALK, ensartinib also potently inhibits TRKA fusions, TRKC, ROS1, EphA2
, and c-MET.
Mcleod et al., "miR-302b inhibits tumorigenesis by targeting EphA2
via Wnt/ [beta]-catenin/ EMT signaling cascade in gastric cancer," BMC Cancer, vol.
With these toxicities in mind, the selection of target antigen, which is strictly specific to the tumor (e.g., EphA2
 and mutated EGFRvIII [31, 32]) or on the category of nonessential tissues (e.g., thymic stromal lymphopoietin [33, 34] and CD33 [35, 36]), is probably the most critical determinant to broaden the application.
"Male hormones," the authors further explain, "facilitate Kaposi's sarcoma-associated herpesvirus infection through activation of viral receptor EphA2
At present congenital cataract is associated with mutation in more than 18 known genes that include; FTL, CRYGC, CRYBB2, CRYBA1, EPHA2
, CRYAB, CHMP4B.
Brantley-Sieders et al., "Inhibition of retinal neovascularization by soluble EphA2
receptor," Experimental Eye Research, vol.
overexpression correlates with poor prognosis in esophageal squamous cell carcinoma," International Journal of Cancer, vol.
These are the EphA2
null mouse  and PAK4 null mouse .
A series of researches have demonstrated that hub genes in CRC, such as DHRS9 , GRIM-19 , EphA2
, and STYK1 ,not only are involved in regulating a variety of cellular processes including cell proliferation, survival, differentiation, migration, and apoptosis but are also correlated with disease progression and prognosis of patients with CRC.
EGFR and EphA2
are host factors for hepatitis C virus entry and possible targets for antiviral therapy.
We first selected the 36 most important biological modules (CDK4, CDK6, CDK2AP2, BC[L.SUB.2], XIAP, BAX, CASP3, CASP8, CASP9, FOXA2, HNF4A, EBP, HGF, NFKB2, STAT3, IL6, I[L.SUB.1]0, HIF1AN, MYC, GSK3B, TP53, PTEN, RB1, MDM2, PDGFRA, SOX2, PIK3CA, FGFR1, IGF1R, EPHA2
, MET, EGFR, DDR2, KEAP1, KRAS, and AKT1) out of the whole genome for lung cancer according to .