beta-lactamase

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be·ta-lac·ta·mase

 (bā′tə-lăk′tə-mās′, -māz′, bē′-)
n.
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

[beta-lactam, cyclic amide occurring in penicillins (beta + lact(one) + am(ide)) + -ase.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.beta-lactamase - enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations

be·ta-lac·ta·mase

a. beta-lactamasa, enzima que destruye el conjunto de beta-lactam antibióticos penicílicos haciéndolos no efectivos;
beta-lactamase resistanceresistencia de beta-lactamasa, a algunos tipos de penicilina.
English-Spanish Medical Dictionary © Farlex 2012
References in periodicals archive ?
All Gram-negative bacilli isolates which showed a diameter of inhibition zone less than 17 mm for ceftazidime, less than 19 mm for ceftriaxone and less than 22 mm for cefotaxime were selected for testing ESBL enzyme production using Double Disc Synergy Test (DDST) as previously reported.
Commercially available beta-lactamase inhibitors i.e., calvlanic acid and sulbactam or tazobactam, inhibit the ESBLs (TEM and SHV family) to some extent.7,8 Sulbactum or clavulanic acid are used as ESBL inhibitors.
A high rate of clinical failure among patients who were infected with ESBL producing bacteria and who received initial antimicrobial therapy, especially cephalosporin has been demonstrated.
The [beta]-lactamases were screened for ESBL, AmpC, and carbapenemases by double disc diffusion test with discs containing clavulanic acid (4 [micro]g/mL), boronic acid (400 [micro]g/mL) and EDTA (320 [micro]g/mL).
Second, we examined the contribution of food-origin isolates to locally disseminated ESBL E.
The ceftriaxone of 30 microgram and cefazidime of 30 microgram (15mm apart), including a disk of augmentin 20 +10 micrograms) disks were used for screening of ESBL producing microorganism (Wayne, PA.
There are several risk factors that may contribute to the prevalence of ESBL infection among patients and healthcare workers.
The present study screened 32 Enterobacteriaceae isolates from various Equine samples and specimens from organised studs by antibiotic susceptibility testing (ABST) and isolated 10 multi drug resistant Enterobacteriaceae strains which were further screened for ESBL, Amp C [beta]-lactamases and
ESBL enzymes, which are largely plasmid mediated, are capable of hydrolyzing ESCs and aztreonam, but are inhibited by clavulanic acid, tazobactam or sulbactam (5).
In Saudi Arabia, previous studies have been conducted to determine the prevalence of ESBL-producing Enterobacteriaceae (EPE), with CTX-M enzymes being the most common ESBL type [23-30].