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Effect of Erythroxylum coca, cocaine and ecgonine methyl ester as dietary supplements on energy metabolism in the rat.
Most of the cocaine, benzoylecgonine, and ecgonine methyl ester was excreted within 24 h into the sweat; however, a washout period up to 2 weeks after use was observed (15).
 have made possible the semiquantification of cocaine and its metabolites (benzoylecgonine, cocaethylene, and ecgonine methyl ester) in hair, using microarrays for MS and MALDI-MS/MS.
Cocaine and its metabolites BZE and ecgonine methyl ester , and
The main route of transformation is enzymatic hydrolysis, and plasmatic (BChE) and hepatic (hCE-1) esterases are the main enzymes responsible for forming its metabolites: ecgonine methyl ester, ecgonine, and benzoylecgonine (figure 1A).
Prosecutors charged him with consuming cocaine and benzoyl ecgonine (a metabolite of cocaine).
Provide an option for screening first for urine creatinine and then for a panel that includes amphetamines/methamphetamines, cocaine (e.g., benzoyl ecgonine), cannabinoids (e.g., marijuana/THC metabolite), and opiates.
(ii) 5 kilograms or more of a mixture or substance containing a detectable amount of (I) coca leaves, except coca leaves and extracts of coca leaves from which cocaine, ecgonine, and derivatives of ecgonine or their salts have been removed;
Analysis of cocaine, benzoylecgonine, ecgonine methyl ester, ethylcocaine and norcocaine in human urine using HPLC with post-column ion-pair extraction and fluorescence detection.
Target list 60 70 80 90 Methyl salicylate X X X X Nicotine X X X X Ecgonine methyl ester X X X X Cotinine X X X X Diphenhydramine X X X X Etomidate X X X X Levamisole X X X X Cocaine X X X X Benzoylecgonine X X X X Midazolam X X X X Propofol X X Mepivacaine X X Caffeine X Acetaminophen X Butalbital X TABLE 2: List of drugs identified by the five platform configurations for three patient specimens.
BChE metabolizes cocaine into ecgonine methyl ester and benzoic acid, which have little toxicity and lack rewarding actions.
Cocaine is extensively metabolized, forming the metabolites benzoylecgonine, ecgonine methyl ester, and ecgonine.
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