Epigenetic imprinting - definition of Epigenetic imprinting by The Free Dictionary
epigenetics (redirected from Epigenetic imprinting)
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n. (used with a sing. verb)
The study of heritable changes in gene expression that are caused by factors such as DNA methylation rather than by a change in the sequence of base pairs in DNA itself.
(functioning as sing
(Genetics) the study of heritable changes that occur without a change in the DNA sequence
References in periodicals archive
Isolated PTH resistance (PHPIb) can result from mutations within the GNAS1 gene but is more commonly caused by epigenetic imprinting
abnormalities affecting the upstream exon 1A (9).
These alterations, that persist through life, are induced by the mechanism of epigenetic imprinting
(cell programming) [2,3].
Fortunately, the effects of epigenetic imprinting
can potentially be reversed in cases where environmental toxins affect the epigenome of the developing fetus (Dolinoy & Jirtle, 2008) so that methyl groups can be removed by environmental conditions (Holliday, 1990).