epigenetics

(redirected from Epimutation)
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ep·i·ge·net·ics

 (ĕp′ĭ-jə-nĕt′ĭks)
n. (used with a sing. verb)
The study of heritable changes in gene expression that are caused by factors such as DNA methylation rather than by a change in the sequence of base pairs in DNA itself.

epigenetics

(ˌɛpɪdʒɪˈnɛtɪks)
n (functioning as sing)
(Genetics) the study of heritable changes that occur without a change in the DNA sequence
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Accordingly, I have 3 specific objectives of this proposal: i) I plan to carry out a comprehensive in vitro epi-drug screen to determine which enzymatic targets have the greatest anti-neoplastic activity; from this, ii) I will characterize the epigenomic changes that underpin such phenotypic rescue; finally, iii) I will compare the therapeutic effects of the top global-acting epi-drug versus target-specific epigenetic editing (Epi-CRISPR) of the most recurrent epimutation in vivo.
LE: SENS Foundation has been investigating the possibility that mutation and epimutation (changes in gene expression rather than alterations of the genes themselves) may be deleterious in ways other than cancer.
Evidence of constitutional MLH1 epimutation associated to transgenerational inheritance of cancer susceptibility.
5) That is, the initial exposure to DDT may have caused an epimutation in a would-be parent and this aberrant pattern was later inherited.
A rare constitutional epimutation of MLH1 has also been reported, (47) potentially adding even further complexity to genetic testing for LS.
Epimutation of the telomeric imprinting center region on chromosome 11p15 in Silver-Russell syndrome.
Allelespecific germ cell epimutation in the spacer promoter of the 45S ribosomal RNA gene after Cr(III) exposure.
Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations.
Of note, cases of constitutional MLH1 epimutations have been described where the promoter of one MLH1 allele is hypermethylated in the germline, resulting in transcriptional silencing of the allele in nonneoplastic tissue.
This understanding may allow for improvement of healthy aging by reversing disease-prone epimutations involved in chronic inflammatory and metabolic disorders.