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A small molecular region of an antigen that binds to a particular antibody or antigen receptor on a T cell; an antigenic determinant. A single antigen can have multiple epitopes.

[epi- + Greek topos, place, spot.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Medicine) the site on an antigen at which a specific antibody becomes attached
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈɛp ɪˌtoʊp)

a site on an antigen at which an antibody can bind, the molecular arrangement of the site determining the specific combining antibody. Also called antigenic determinant .
[1970–75; epi- + -tope < Greek tópos place; compare topo-]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.epitope - the site on the surface of an antigen molecule to which an antibody attaches itself
immunology - the branch of medical science that studies the body's immune system
site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides"
antigen - any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
The title of her presentation was "Vaccination with DerG LEAPS peptide conjugates incorporating distinct PG (aggrecan) epitopes protects by different immune mechanisms in the PG G1 domain induced mouse model of rheumatoid arthritis."
The conclusion was that vaccination with DerG LEAPS conjugates of distinct PG epitopes alone or together were effective at modulating the inflammatory response and arresting the progression of arthritis.
Diagnostic performance and T-cell epitopes may be different in cattle compared to humans; it is therefore necessary to identify and verify these promising T-cell epitopes in individuals.
These antigens are more changeable but the new virus targets part of them called epitopes which vary much less in different strains.
But the new vaccine targets part of the antigens called epitopes. The epitopes vary far less in different strains.
SIT can be improved by using recombinant allergens, which contain most of the IgE-binding epitopes of the source allergens and are pure and better standardized compared to natural allergen extracts (5).
It describes influenza vaccines comprised of multiple copies of several epitopes, such as M-001, which contains nine common and conserved influenza virus epitopes.
Multiple antigenic peptides (MAPs) are dendrimeric (branched) macromolecules built from a lysine core from which a defined number of epitopes radiate [17,18].
The linear B-cell epitopes in the primary amino acid sequence of the coat protein was performed using BCPREDS server with default parameters (http://ailab.cs.iastate.edu/ bcpreds/) which implements a support vector machine (SVM) and the subsequence kernel method (El-Manzalawy et al., 2008a).
In this study, we showed that the epitope changes of [gamma]c protein, in which at least 3 epitopes are concealed, is rapidly induced by the binding between IL-7 and IL-7 receptor core, and such epitope masking of [gamma]c is reversely induced with IL-7R[alpha] expression.
It was shown experimentally that a synthetic peptide can mimic the structure of epitopes and induce an immune response against the native proteins of bacteria causing Salmonellosis and Chlamydia infection [37, 38].
'The components of this universal flu vaccine would be short flu virus fragments - called epitopes - that are already known to be recognised by the immune system.