1 Polycythaemias can also be classified according to the response of their erythroid progenitor cells
to growth factors like erythropoietin or the circulating levels of it.
HPV-B19 exhibits a marked tropism to human BM and replicates only in erythroid progenitor cells
, acting as a confounding but treatable agent in immunocompromised patients.
Moreover, the evidence that ERK inhibitor U0126 has the ability to stimulate [gamma]-globin gene expression and HbF production in human erythroid progenitor cells
suggested the inhibition of ERK can possibly lead to the promotion of HbF production .
PRCA exists in several forms, and the most common is an acute self-limited condition (10) that is secondary to virus- and drug-induced impairment of erythroid progenitor cells
Primary polycythemia relates to defects in erythroid progenitor cells
(EPCs), with polycythemia vera being the most common form (7), (8).
ACD is immune driven where inflammatory cytokines and cells of the reticuloendothelial system (RES) induce changes in iron homeostasis, the proliferation of erythroid progenitor cells
, the production of erythropoietin (EPO), and the life span of the red cell.