estramustine


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es·tra·mus·tine

 (ĕs′trə-mŭs′tēn′)
n.
A drug, C23H31Cl2NO3, that combines the actions of estrogen and nitrogen mustard in the treatment of prostate cancer.

References in periodicals archive ?
Docetaxel and estramustine compared with mitoxantrone and prednisone for advancedrefractory prostate cancer.
Use of estramustine in combination with other cytotoxic agents is not recommended due to the increased risk of clinically important toxicities.
2] q week SWOG 9916 Docetaxel + Mitoxantrone + 770 estramustine prednisone TROPIC Prednisone + Prednisone + 755 cabazitaxel mitoxantrone COU-AA-301 Prednisone + Prednisolone + 1195 abiraterone acetate placebo AFFIRM Enzalutamide Placebo 1199 ALSYMPCA Alpharadin Placebo 922 ([sup.
Examples: Taxanes, epothilones, vinca alkaloids, and estramustine Corticosteroids: useful for killing or slowing cancer cells, but also used as anti-emetics and/or to prevent hypersensitivity reactions.
There are different activities but generally these drugs stabilise the overall microtubule structure and resist the depolymerization that occurs during mitosis, so the cells remain frozen or arrested at this (M) phase of the cell cycle An example of an antimicrotubule drug is Estramustine.
66-69) Neoadjuvant chemotherapy with estramustine also produces comparable outcome.
Data from two studies presented at the annual meeting of the American Society of Clinical Oncology showed that docetaxel, alone or in combination with estramustine, can add several months to the mean survival time for men with advanced, hormone-refractory prostate cancer.
Drugs that might interfere with the results of monitoring tests Antineoplastic drugs Other drugs Azacitidine Atropine Busulfan Chloral hydrate Chlorambucil Chlordiazepoxide Cisplatin Chlorpromazine Cyclophosphamide Cimetidine Cytarabine Diazepam Dacarbazine Dobutamine Dibromodulcitol Dopamine Estramustine Ephedrine Floxuridine Fentanyl Fludarabine Haloperidol Fluorouracil Hydroxyzine Ifosfamide Meperidine Lomustine Metoclopramide Mercaptopurine Midazolam Methotrexate Morphine Streptozocin Pentobarbital Thiopeta Phenylephrine Prochlorperazine Promethazine Ranitidine Scopolamine Secobarbital Temazepam
Most notably, he served as the PI for a randomized trial comparing docetaxel and estramustine to mitoxantrone and prednisone in men with hormone refractory prostate cancer.
Efficacy of estramustine phosphate according to risk classification of castration-resistant prostate cancer.
A parallel study comparing Taxotere and estramustine (Emcyt), an antineoplastic compound that contains estradiol and is approved for prostate cancer, to mitoxantrone and prednisone found about a 1.